DegronMD

Uniprot ID: Q9Y2L9

Source protein: Leucine-rich repeat and calponin homology domain-containing protein 1

Source gene: LRCH1

Class: DEG_SCF_FBW7_2

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.9768

ASA_SCORE: 95.5143

COIL: 0.9597

CONS_SCORE: 0.3312

DSS_SCORE: 0.8897

HELIX: 0.017

FCONS_SCORE: 1.3197

RIG_SCORE: 0.6053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S16L	TCGA-BH-A18P	BRCA	TCGA	MATPGSE	DEG_SCF_FBW7_2	0.0833
p.S16L	TCGA-UC-A7PI	CESC	TCGA	MATPGSE	DEG_SCF_FBW7_2	0.0833
p.S16L	DO3346	BRCA	ICGC	MATPGSE	DEG_SCF_FBW7_2	0.0833
p.S16L	DO51616	CESC	ICGC	MATPGSE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2L9	Leucine-rich repeat and calponin homology domain-containing protein 1	DEG_SCF_FBW7_2	1:7	MATPGSE	FBXW7	0.9768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons