DegronMD

Uniprot ID: O75995

Source protein: SAM and SH3 domain-containing protein 3

Source gene: SASH3

Class: DEG_SCF_TRCP1_1

Location: 56:61

E3 ligase: BTRC

DEGRON score: 0.996

ASA_SCORE: 71.9

COIL: 0.946

CONS_SCORE: 0.64

DSS_SCORE: 0.703

HELIX: 0.0385

FCONS_SCORE: 1.0516

RIG_SCORE: 0.6383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P60H	TCGA-DZ-6131	KIRP	TCGA	DSGVPT	DEG_SCF_TRCP1_1	0.6583
p.P60H	DO20911	KIRP	ICGC	DSGVPT	DEG_SCF_TRCP1_1	0.6583
p.D64Y	SIDM00168	Head and Neck Carcinoma	GDSC	DSGVPT	DEG_SCF_TRCP1_1	0.25
p.D64Y	ACH-000549	Head and Neck Cancer	CCLE	DSGVPT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75995	SAM and SH3 domain-containing protein 3	DEG_SCF_TRCP1_1	56:61	DSGVPT	BTRC	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons