DegronMD

Uniprot ID: P00451

Source protein: Coagulation factor VIII

Source gene: F8

Class: DEG_SCF_TRCP1_1

Location: 1444:1450

E3 ligase: BTRC

DEGRON score: 0.9946

ASA_SCORE: 78.2

COIL: 0.7567

CONS_SCORE: 0.5368

DSS_SCORE: 0.4509

HELIX: 0.1023

FCONS_SCORE: 1.2824

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1444G	TCGA-69-7979	LUAD	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.7198
p.D1444G	DO23874	LUAD	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.7198
p.K1459Q	TCGA-AG-A01W	READ	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.1944
p.K1459Q	DO36382	READ	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.1944
p.K1442N	TCGA-AX-A06F	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.2778
p.K1442N	TCGA-EO-A3B0	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.2778
p.K1442N	DO219773	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.2778
p.K1442N	DO41752	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.2778
p.G1446E	TCGA-CA-5796	COAD	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.7199
p.G1446E	DO7777	COAD	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.7199
p.S1445Y	TCGA-EO-A3B0	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	0.712
p.S1445Y	DO219773	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.712
p.H1434Y	DO225046	BRCA	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.0556
p.V1447F	DO230550	LUSC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	0.5957
p.N1460I	SIDM00889	Cervical Carcinoma	GDSC	DSGVQES	DEG_SCF_TRCP1_1	0.0556
p.H1452L	SIDM00282	Colorectal Carcinoma	GDSC	DSGVQES	DEG_SCF_TRCP1_1	0.2778
p.H1452L	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGVQES	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00451	Coagulation factor VIII	DEG_SCF_TRCP1_1	1444:1450	DSGVQES	BTRC	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons