DegronMD - P00451(F8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1704H	TCGA-28-1745	GBM	TCGA	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.25
p.N1704H	DO13977	GBM	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.25
p.A1741T	TCGA-29-1761	OV	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.0833
p.A1741T	DO32207	OV	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.0833
p.E1701K	TCGA-55-A4DF	LUAD	TCGA	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.7022
p.E1701K	DO45318	LUAD	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.7022
p.D1444G	TCGA-69-7979	LUAD	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.7198
p.D1444G	DO23874	LUAD	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.7198
p.K1459Q	TCGA-AG-A01W	READ	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation substituting flanking lysine	0.1944
p.K1459Q	DO36382	READ	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation substituting flanking lysine	0.1944
p.S1743I	TCGA-AP-A059	UCEC	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.1389
p.S1743I	DO41361	UCEC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.1389
p.S1709R	TCGA-AR-A24Q	BRCA	TCGA	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1111
p.S1709R	DO3524	BRCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1111
p.K1442N	TCGA-AX-A06F	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.K1442N	TCGA-EO-A3B0	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.K1442N	DO219773	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.K1442N	DO41752	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.G1446E	TCGA-CA-5796	COAD	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.7199
p.G1446E	DO7777	COAD	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.7199
p.G1760C	TCGA-D3-A2JB	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.2222
p.G1760C	DO47607	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.2222
p.P1747S	TCGA-D3-A5GO	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.25
p.P1747S	DO47419	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.25
p.S922F	TCGA-EB-A41A	SKCM	TCGA	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1667
p.S922F	DO37429	SKCM	ICGC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1667
p.D1702N	TCGA-EE-A2GO	SKCM	TCGA	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.3056
p.D1702N	DO37823	SKCM	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.3056
p.S1445Y	TCGA-EO-A3B0	UCEC	TCGA	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.712
p.S1445Y	DO219773	UCEC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.712
p.P1747T	TCGA-ER-A19N	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.25
p.P1747T	DO37452	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.25
p.T1763A	TCGA-FI-A2D5	UCEC	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.1389
p.T1763A	DO41331	UCEC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation rewiring degron network	0.1389
p.D933N	TCGA-FS-A4FC	SKCM	TCGA	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.6932
p.D933N	DO37762	SKCM	ICGC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.6932
p.L923V	TCGA-RD-A7C1	STAD	TCGA	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.L923V	DO233171	GACA	ICGC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.L923V	DO50132	STAD	ICGC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.E1690G	TCGA-ZJ-AAXI	CESC	TCGA	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	DO219756	CESC	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	SIDM00496	Thyroid Gland Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	SIDM01144	Gastric Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	ACH-000303	Gastric Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	ACH-001350	Thyroid Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	HTC-C3	thyroid	COSMIC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1690G	NCI-SNU-5	stomach	COSMIC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1667
p.E1703G	DO225076	BRCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.2778
p.H1434Y	DO225046	BRCA	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.0556
p.R1708H	DO228927	COCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.1389
p.Q1755K	DO228976	LICA	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.5833
p.Q1755L	DO23130	LINC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.6654
p.V1447F	DO230550	LUSC	ICGC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation altering degron motif	0.5957
p.H931Y	DO222504	MELA	ICGC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.6118
p.E1756K	DO229456	SKCA	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.7022
p.E1756K	SIDM00545	Melanoma	GDSC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.7022
p.E1756K	ACH-000987	Skin Cancer	CCLE	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.7022
p.E1756K	Mewo	skin	COSMIC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	1750:1756	Mutation altering degron motif	0.7022
p.Y1699N	DO229257	THCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.7059
p.V930I	SIDM00362	Burkitt's Lymphoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.5965
p.V930I	ACH-002293	Lymphoma	CCLE	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.5965
p.V930I	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.5965
p.N1460I	SIDM00889	Cervical Carcinoma	GDSC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.0556
p.Y1699F	SIDM00568	Gastric Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.6417
p.Y1699F	ACH-000247	Gastric Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.6417
p.Y1699F	OCUM-1	stomach	COSMIC	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation altering degron motif	0.6417
p.H1452L	SIDM00282	Colorectal Carcinoma	GDSC	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.H1452L	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGVQES	DEG_SCF_TRCP1_1	1444:1450	Mutation rewiring degron network	0.2778
p.M928K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.8062
p.M928K	ACH-000916	Lung Cancer	CCLE	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.8062
p.M928K	NCI-H1573	lung	COSMIC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation altering degron motif	0.8062
p.T938I	SIDM01228	Melanoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.T938I	ACH-001024	Skin Cancer	CCLE	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.T938I	CHL-1	skin	COSMIC	MPVHYD	LIG_APCC_ABBA_1	928:933	Mutation rewiring degron network	0.1944
p.D1695N	ACH-000918	Leukemia	CCLE	FDIYDE	LIG_APCC_ABBA_1	1696:1701	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F8

UniProt ID: P00451

Entrez ID: 2157

Protein name: Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for F8 in