DegronMD

Uniprot ID: P00451

Source protein: Coagulation factor VIII

Source gene: F8

Class: LIG_APCC_ABBAyCdc20_2

Location: 1750:1756

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6484

ASA_SCORE: 38.3857

COIL: 0.1057

CONS_SCORE: 0.8487

DSS_SCORE: 0.291

HELIX: 0.0117

FCONS_SCORE: 1.2825

RIG_SCORE: 0.8486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1741T	TCGA-29-1761	OV	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A1741T	DO32207	OV	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S1743I	TCGA-AP-A059	UCEC	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1743I	DO41361	UCEC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1760C	TCGA-D3-A2JB	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1760C	DO47607	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1747S	TCGA-D3-A5GO	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.P1747S	DO47419	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.P1747T	TCGA-ER-A19N	SKCM	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.P1747T	DO37452	SKCM	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.T1763A	TCGA-FI-A2D5	UCEC	TCGA	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T1763A	DO41331	UCEC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q1755K	DO228976	LICA	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.5833
p.Q1755L	DO23130	LINC	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.6654
p.E1756K	DO229456	SKCA	ICGC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1756K	SIDM00545	Melanoma	GDSC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1756K	ACH-000987	Skin Cancer	CCLE	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1756K	Mewo	skin	COSMIC	KKVVFQE	LIG_APCC_ABBAyCdc20_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00451	Coagulation factor VIII	LIG_APCC_ABBAyCdc20_2	1750:1756	KKVVFQE	APC,CDC20,FZR1	0.6484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons