DegronMD

Uniprot ID: P00451

Source protein: Coagulation factor VIII

Source gene: F8

Class: LIG_APCC_ABBA_1

Location: 1696:1701

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8035

ASA_SCORE: 60.1667

COIL: 0.3597

CONS_SCORE: 0.8302

DSS_SCORE: 0.5292

HELIX: 0.0493

FCONS_SCORE: 1.298

RIG_SCORE: 0.8199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1704H	TCGA-28-1745	GBM	TCGA	FDIYDE	LIG_APCC_ABBA_1	0.25
p.N1704H	DO13977	GBM	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.25
p.E1701K	TCGA-55-A4DF	LUAD	TCGA	FDIYDE	LIG_APCC_ABBA_1	0.7022
p.E1701K	DO45318	LUAD	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.7022
p.S1709R	TCGA-AR-A24Q	BRCA	TCGA	FDIYDE	LIG_APCC_ABBA_1	0.1111
p.S1709R	DO3524	BRCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.1111
p.D1702N	TCGA-EE-A2GO	SKCM	TCGA	FDIYDE	LIG_APCC_ABBA_1	0.3056
p.D1702N	DO37823	SKCM	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.3056
p.E1690G	TCGA-ZJ-AAXI	CESC	TCGA	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	DO219756	CESC	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	SIDM00496	Thyroid Gland Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	SIDM01144	Gastric Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	ACH-000303	Gastric Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	ACH-001350	Thyroid Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	HTC-C3	thyroid	COSMIC	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1690G	NCI-SNU-5	stomach	COSMIC	FDIYDE	LIG_APCC_ABBA_1	0.1667
p.E1703G	DO225076	BRCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.2778
p.R1708H	DO228927	COCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.1389
p.Y1699N	DO229257	THCA	ICGC	FDIYDE	LIG_APCC_ABBA_1	0.7059
p.Y1699F	SIDM00568	Gastric Carcinoma	GDSC	FDIYDE	LIG_APCC_ABBA_1	0.6417
p.Y1699F	ACH-000247	Gastric Cancer	CCLE	FDIYDE	LIG_APCC_ABBA_1	0.6417
p.Y1699F	OCUM-1	stomach	COSMIC	FDIYDE	LIG_APCC_ABBA_1	0.6417
p.D1695N	ACH-000918	Leukemia	CCLE	FDIYDE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00451	Coagulation factor VIII	LIG_APCC_ABBA_1	1696:1701	FDIYDE	APC,CDC20,FZR1	0.8035	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons