DegronMD

Uniprot ID: P00451

Source protein: Coagulation factor VIII

Source gene: F8

Class: LIG_APCC_ABBA_1

Location: 928:933

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9676

ASA_SCORE: 72.4

COIL: 0.7395

CONS_SCORE: 0.3029

DSS_SCORE: 0.5716

HELIX: 0.1293

FCONS_SCORE: 0.7407

RIG_SCORE: 0.7073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S922F	TCGA-EB-A41A	SKCM	TCGA	MPVHYD	LIG_APCC_ABBA_1	0.1667
p.S922F	DO37429	SKCM	ICGC	MPVHYD	LIG_APCC_ABBA_1	0.1667
p.D933N	TCGA-FS-A4FC	SKCM	TCGA	MPVHYD	LIG_APCC_ABBA_1	0.6932
p.D933N	DO37762	SKCM	ICGC	MPVHYD	LIG_APCC_ABBA_1	0.6932
p.L923V	TCGA-RD-A7C1	STAD	TCGA	MPVHYD	LIG_APCC_ABBA_1	0.1944
p.L923V	DO233171	GACA	ICGC	MPVHYD	LIG_APCC_ABBA_1	0.1944
p.L923V	DO50132	STAD	ICGC	MPVHYD	LIG_APCC_ABBA_1	0.1944
p.H931Y	DO222504	MELA	ICGC	MPVHYD	LIG_APCC_ABBA_1	0.6118
p.V930I	SIDM00362	Burkitt's Lymphoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	0.5965
p.V930I	ACH-002293	Lymphoma	CCLE	MPVHYD	LIG_APCC_ABBA_1	0.5965
p.V930I	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	MPVHYD	LIG_APCC_ABBA_1	0.5965
p.M928K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	0.8062
p.M928K	ACH-000916	Lung Cancer	CCLE	MPVHYD	LIG_APCC_ABBA_1	0.8062
p.M928K	NCI-H1573	lung	COSMIC	MPVHYD	LIG_APCC_ABBA_1	0.8062
p.T938I	SIDM01228	Melanoma	GDSC	MPVHYD	LIG_APCC_ABBA_1	0.1944
p.T938I	ACH-001024	Skin Cancer	CCLE	MPVHYD	LIG_APCC_ABBA_1	0.1944
p.T938I	CHL-1	skin	COSMIC	MPVHYD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00451	Coagulation factor VIII	LIG_APCC_ABBA_1	928:933	MPVHYD	APC,CDC20,FZR1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons