DegronMD

Uniprot ID: O43347

Source protein: RNA-binding protein Musashi homolog 1

Source gene: MSI1

Class: DEG_SCF_TRCP1_1

Location: 326:331

E3 ligase: BTRC

DEGRON score: 0.7151

ASA_SCORE: 43.8667

COIL: 0.8362

CONS_SCORE: 0.3774

DSS_SCORE: 0.3357

HELIX: 0.12

FCONS_SCORE: 0.8614

RIG_SCORE: 0.6992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S327L	TCGA-CG-4460	STAD	TCGA	DSGVSS	DEG_SCF_TRCP1_1	0.7667
p.S327L	DO38427	STAD	ICGC	DSGVSS	DEG_SCF_TRCP1_1	0.7667
p.A335V	TCGA-FI-A2D0	UCEC	TCGA	DSGVSS	DEG_SCF_TRCP1_1	0.2222
p.A335V	DO43891	UCEC	ICGC	DSGVSS	DEG_SCF_TRCP1_1	0.2222
p.D326G	DO233807	GACA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	0.7198
p.Y320C	DO229151	THCA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	0.1667
p.A323T	DO229211	THCA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	0.25
p.S331R	SIDM02039	Colorectal Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	0.7427
p.S330N	SIDM01943	Colorectal Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	0.5958
p.G321V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	0.1944
p.G321V	EMC-BAC-1	lung	COSMIC	DSGVSS	DEG_SCF_TRCP1_1	0.1944
p.G321R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	0.1944
p.G321R	EMC-BAC-1	lung	COSMIC	DSGVSS	DEG_SCF_TRCP1_1	0.1944
p.A322V	ACH-001498	Lymphoma	CCLE	DSGVSS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43347	RNA-binding protein Musashi homolog 1	DEG_SCF_TRCP1_1	326:331	DSGVSS	BTRC	0.7151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons