DegronMD - O43347(MSI1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A264V	TCGA-85-A4QR	LUSC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.A264V	TCGA-85-A4QR	LUSC	TCGA	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.A264V	DO45523	LUSC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.A264V	DO45523	LUSC	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.G271R	TCGA-AJ-A3OK	UCEC	TCGA	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0556
p.G271R	DO222765	COCA	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0556
p.G271R	DO43602	UCEC	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0556
p.G271R	ACH-000398	Lymphoma	CCLE	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.0556
p.A264T	TCGA-B5-A1MX	UCEC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.A264T	TCGA-B5-A1MX	UCEC	TCGA	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.A264T	DO41999	UCEC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation rewiring degron network	0.0833
p.A264T	DO41999	UCEC	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation rewiring degron network	0.25
p.S229R	TCGA-BH-A0WA	BRCA	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1667
p.S229R	DO2897	BRCA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1667
p.S327L	TCGA-CG-4460	STAD	TCGA	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation altering degron motif	0.7667
p.S327L	DO38427	STAD	ICGC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation altering degron motif	0.7667
p.T311A	TCGA-CK-5916	COAD	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1389
p.T311A	DO8786	COAD	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1389
p.T292M	TCGA-D6-A6EO	HNSC	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1944
p.T292M	DO230319	COCA	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1944
p.T292M	DO52083	HNSC	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1944
p.P313L	TCGA-ER-A193	SKCM	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.P313L	DO47368	SKCM	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.P254Q	TCGA-ER-A19P	SKCM	TCGA	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5924
p.P254Q	TCGA-ER-A19P	SKCM	TCGA	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7035
p.P254Q	TCGA-P3-A6T3	HNSC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5924
p.P254Q	TCGA-P3-A6T3	HNSC	TCGA	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7035
p.P254Q	DO49055	HNSC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5924
p.P254Q	DO49055	HNSC	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7035
p.P254Q	DO47623	SKCM	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5924
p.P254Q	DO47623	SKCM	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7035
p.A335V	TCGA-FI-A2D0	UCEC	TCGA	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.2222
p.A335V	DO43891	UCEC	ICGC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.2222
p.R230L	TCGA-FS-A1ZG	SKCM	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.R230L	TCGA-VS-A9V2	CESC	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.R230L	DO51649	CESC	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.R230L	DO37523	SKCM	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.G234V	TCGA-TQ-A8XE	LGG	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.3056
p.G234V	DO223700	LGG	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.3056
p.R250Q	DO230343	COCA	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.6218
p.R247C	DO222729	COCA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation altering degron motif	0.719
p.D326G	DO233807	GACA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation altering degron motif	0.7198
p.F246L	DO229015	LICA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation altering degron motif	0.587
p.S255R	DO231618	LINC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.8538
p.S255R	DO231618	LINC	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7427
p.L308Q	DO45029	LINC	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.A294T	DO232761	PBCA	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.25
p.Y320C	DO229151	THCA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.1667
p.P260S	DO229259	THCA	ICGC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.6752
p.A323T	DO229211	THCA	ICGC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.25
p.S331R	SIDM02039	Colorectal Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation altering degron motif	0.7427
p.S330N	SIDM01943	Colorectal Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation altering degron motif	0.5958
p.T251S	SIDM00845	Burkitt's Lymphoma	GDSC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.8227
p.T251S	ACH-000786	Lymphoma	CCLE	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.8227
p.A228T	SIDM00636	Non-Cancerous	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1389
p.A228T	SIDM00631	Breast Carcinoma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1389
p.A228T	SIDM00467	Acute Myeloid Leukemia	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1389
p.A228T	SIDM01554	Mesothelioma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1389
p.T300S	SIDM00282	Colorectal Carcinoma	GDSC	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7116
p.G321V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.1944
p.G321V	EMC-BAC-1	lung	COSMIC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.1944
p.G321R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.1944
p.G321R	EMC-BAC-1	lung	COSMIC	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.1944
p.R230Q	SIDM00126	Melanoma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.R230Q	ACH-002147	Skin Cancer	CCLE	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.R230Q	K2	skin	COSMIC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	235:248	Mutation rewiring degron network	0.1944
p.E249D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5647
p.E249D	ACH-001498	Lymphoma	CCLE	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5647
p.E249D	Farage	haematopoietic and lymphoid tissue	COSMIC	VERTPLPS	DEG_SCF_FBW7_1	248:255	Mutation altering degron motif	0.5647
p.A256T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7139
p.A256T	ACH-000942	Leukemia	CCLE	LPSAPVLPE	DEG_SIAH_1	253:261	Mutation altering degron motif	0.7139
p.R303H	ACH-000530	Lung Cancer	CCLE	PGSTPSRT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7133
p.A322V	ACH-001498	Lymphoma	CCLE	DSGVSS	DEG_SCF_TRCP1_1	326:331	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSI1

UniProt ID: O43347

Entrez ID: 4440

Protein name: RNA-binding protein Musashi homolog 1 (Musashi-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSI1 in