DegronMD

Uniprot ID: O43347

Source protein: RNA-binding protein Musashi homolog 1

Source gene: MSI1

Class: DEG_SIAH_1

Location: 253:261

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9411

ASA_SCORE: 19.8889

COIL: 0.883

CONS_SCORE: 0.3257

DSS_SCORE: 0.2858

HELIX: 0.0521

FCONS_SCORE: 0.8447

RIG_SCORE: 0.7803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A264V	TCGA-85-A4QR	LUSC	TCGA	LPSAPVLPE	DEG_SIAH_1	0.25
p.A264V	DO45523	LUSC	ICGC	LPSAPVLPE	DEG_SIAH_1	0.25
p.G271R	TCGA-AJ-A3OK	UCEC	TCGA	LPSAPVLPE	DEG_SIAH_1	0.0556
p.G271R	DO222765	COCA	ICGC	LPSAPVLPE	DEG_SIAH_1	0.0556
p.G271R	DO43602	UCEC	ICGC	LPSAPVLPE	DEG_SIAH_1	0.0556
p.G271R	ACH-000398	Lymphoma	CCLE	LPSAPVLPE	DEG_SIAH_1	0.0556
p.A264T	TCGA-B5-A1MX	UCEC	TCGA	LPSAPVLPE	DEG_SIAH_1	0.25
p.A264T	DO41999	UCEC	ICGC	LPSAPVLPE	DEG_SIAH_1	0.25
p.P254Q	TCGA-ER-A19P	SKCM	TCGA	LPSAPVLPE	DEG_SIAH_1	0.7035
p.P254Q	TCGA-P3-A6T3	HNSC	TCGA	LPSAPVLPE	DEG_SIAH_1	0.7035
p.P254Q	DO49055	HNSC	ICGC	LPSAPVLPE	DEG_SIAH_1	0.7035
p.P254Q	DO47623	SKCM	ICGC	LPSAPVLPE	DEG_SIAH_1	0.7035
p.S255R	DO231618	LINC	ICGC	LPSAPVLPE	DEG_SIAH_1	0.7427
p.P260S	DO229259	THCA	ICGC	LPSAPVLPE	DEG_SIAH_1	0.6752
p.A256T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LPSAPVLPE	DEG_SIAH_1	0.7139
p.A256T	ACH-000942	Leukemia	CCLE	LPSAPVLPE	DEG_SIAH_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43347	RNA-binding protein Musashi homolog 1	DEG_SIAH_1	253:261	LPSAPVLPE	SIAH1,SIAH2,SIAH3	0.9411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons