DegronMD

Uniprot ID: O43347

Source protein: RNA-binding protein Musashi homolog 1

Source gene: MSI1

Class: DEG_ODPH_VHL_1

Location: 235:248

E3 ligase: VHL

DEGRON score: 0.8466

ASA_SCORE: 13.2214

COIL: 0.8301

CONS_SCORE: 0.3739

DSS_SCORE: 0.2468

HELIX: 0.1021

FCONS_SCORE: 1.0576

RIG_SCORE: 0.808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S229R	TCGA-BH-A0WA	BRCA	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1667
p.S229R	DO2897	BRCA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1667
p.R230L	TCGA-FS-A1ZG	SKCM	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.R230L	TCGA-VS-A9V2	CESC	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.R230L	DO51649	CESC	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.R230L	DO37523	SKCM	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.G234V	TCGA-TQ-A8XE	LGG	TCGA	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.3056
p.G234V	DO223700	LGG	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.3056
p.R247C	DO222729	COCA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.719
p.F246L	DO229015	LICA	ICGC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.587
p.A228T	SIDM00636	Non-Cancerous	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1389
p.A228T	SIDM00631	Breast Carcinoma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1389
p.A228T	SIDM00467	Acute Myeloid Leukemia	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1389
p.A228T	SIDM01554	Mesothelioma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1389
p.R230Q	SIDM00126	Melanoma	GDSC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.R230Q	ACH-002147	Skin Cancer	CCLE	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944
p.R230Q	K2	skin	COSMIC	LAPGYTYQFPEFRV	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43347	RNA-binding protein Musashi homolog 1	DEG_ODPH_VHL_1	235:248	LAPGYTYQFPEFRV	VHL	0.8466	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons