DegronMD

Uniprot ID: O43347

Source protein: RNA-binding protein Musashi homolog 1

Source gene: MSI1

Class: DEG_SCF_FBW7_1

Location: 248:255

E3 ligase: FBXW7

DEGRON score: 0.9142

ASA_SCORE: 26.425

COIL: 0.8994

CONS_SCORE: 0.3153

DSS_SCORE: 0.3044

HELIX: 0.0496

FCONS_SCORE: 0.8374

RIG_SCORE: 0.7793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A264V	TCGA-85-A4QR	LUSC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	0.0833
p.A264V	DO45523	LUSC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.0833
p.A264T	TCGA-B5-A1MX	UCEC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	0.0833
p.A264T	DO41999	UCEC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.0833
p.P254Q	TCGA-ER-A19P	SKCM	TCGA	VERTPLPS	DEG_SCF_FBW7_1	0.5924
p.P254Q	TCGA-P3-A6T3	HNSC	TCGA	VERTPLPS	DEG_SCF_FBW7_1	0.5924
p.P254Q	DO49055	HNSC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.5924
p.P254Q	DO47623	SKCM	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.5924
p.R250Q	DO230343	COCA	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.6218
p.S255R	DO231618	LINC	ICGC	VERTPLPS	DEG_SCF_FBW7_1	0.8538
p.T251S	SIDM00845	Burkitt's Lymphoma	GDSC	VERTPLPS	DEG_SCF_FBW7_1	0.8227
p.T251S	ACH-000786	Lymphoma	CCLE	VERTPLPS	DEG_SCF_FBW7_1	0.8227
p.E249D	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VERTPLPS	DEG_SCF_FBW7_1	0.5647
p.E249D	ACH-001498	Lymphoma	CCLE	VERTPLPS	DEG_SCF_FBW7_1	0.5647
p.E249D	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	VERTPLPS	DEG_SCF_FBW7_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43347	RNA-binding protein Musashi homolog 1	DEG_SCF_FBW7_1	248:255	VERTPLPS	FBXW7	0.9142	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons