DegronMD

Uniprot ID: O43347

Source protein: RNA-binding protein Musashi homolog 1

Source gene: MSI1

Class: DEG_SCF_FBW7_1

Location: 297:304

E3 ligase: FBXW7

DEGRON score: 0.9056

ASA_SCORE: 62.2375

COIL: 0.9373

CONS_SCORE: 0.4175

DSS_SCORE: 0.6353

HELIX: 0.0206

FCONS_SCORE: 0.9462

RIG_SCORE: 0.5732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T311A	TCGA-CK-5916	COAD	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	0.1389
p.T311A	DO8786	COAD	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.1389
p.T292M	TCGA-D6-A6EO	HNSC	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	0.1944
p.T292M	DO230319	COCA	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.1944
p.T292M	DO52083	HNSC	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.1944
p.P313L	TCGA-ER-A193	SKCM	TCGA	PGSTPSRT	DEG_SCF_FBW7_1	0.0833
p.P313L	DO47368	SKCM	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.0833
p.L308Q	DO45029	LINC	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.2222
p.A294T	DO232761	PBCA	ICGC	PGSTPSRT	DEG_SCF_FBW7_1	0.25
p.T300S	SIDM00282	Colorectal Carcinoma	GDSC	PGSTPSRT	DEG_SCF_FBW7_1	0.7116
p.R303H	ACH-000530	Lung Cancer	CCLE	PGSTPSRT	DEG_SCF_FBW7_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43347	RNA-binding protein Musashi homolog 1	DEG_SCF_FBW7_1	297:304	PGSTPSRT	FBXW7	0.9056	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons