DegronMD

Uniprot ID: Q9HC78

Source protein: Zinc finger and BTB domain-containing protein 20

Source gene: ZBTB20

Class: DEG_SCF_TRCP1_1

Location: 376:382

E3 ligase: BTRC

DEGRON score: 0.9971

ASA_SCORE: 74.8429

COIL: 0.879

CONS_SCORE: 0.6741

DSS_SCORE: 0.7958

HELIX: 0.0504

FCONS_SCORE: 1.0614

RIG_SCORE: 0.581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S377L	TCGA-2W-A8YY	CESC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.8778
p.S377L	TCGA-ER-A193	SKCM	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.8778
p.F375V	TCGA-62-8399	LUAD	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.3056
p.P370R	TCGA-77-7337	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.1667
p.S374I	TCGA-77-A5G8	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.2778
p.T385S	TCGA-85-8355	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.25
p.S374R	TCGA-BH-A18Q	BRCA	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.2778
p.I383V	TCGA-F1-6177	STAD	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.3056
p.E367K	TCGA-GS-A9TU	DLBC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	0.0833
p.V372F	DO13024	GBM	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.2222
p.S379F	DO26444	LUSC	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.7982
p.S379F	ACH-000788	Skin Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	0.7982
p.S379F	A2058	skin	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	0.7982
p.S392L	DO220875	MELA	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.0556
p.S392F	DO220875	MELA	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.0556
p.S370I	DO51407	PRAD	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.1667
p.S370N	DO38707	STAD	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	0.1667
p.V379I	SIDM00652	Small Cell Lung Carcinoma	GDSC	DSGVSSS	DEG_SCF_TRCP1_1	0.5965
p.V379I	NCI-H1105	lung	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	0.5965
p.D376N	SIDM01619	Endometrial Carcinoma	GDSC	DSGVSSS	DEG_SCF_TRCP1_1	0.6932
p.D369H	ACH-000348	Skin Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	0.1389
p.D369H	RPMI-7951	skin	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	0.1389
p.N390S	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	0.1111
p.L384P	NCI-H630	large_intestine	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	0.2778
p.S388L	ESO51	oesophagus	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC78	Zinc finger and BTB domain-containing protein 20	DEG_SCF_TRCP1_1	376:382	DSGVSSS	BTRC	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons