DegronMD - Q9HC78(ZBTB20)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S377L	TCGA-2W-A8YY	CESC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.8778
p.S377L	TCGA-ER-A193	SKCM	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.8778
p.F375V	TCGA-62-8399	LUAD	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.3056
p.P370R	TCGA-77-7337	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1667
p.S374I	TCGA-77-A5G8	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.2778
p.E293A	TCGA-78-7155	LUAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0833
p.T385S	TCGA-85-8355	LUSC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.25
p.R294H	TCGA-A5-A0GB	UCEC	TCGA	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1111
p.R300C	TCGA-AB-2854	LAML	TCGA	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.R300C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.R300C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.E307K	TCGA-AM-5820	COAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.591
p.S374R	TCGA-BH-A18Q	BRCA	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.2778
p.R294C	TCGA-CD-A4MG	STAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1111
p.I383V	TCGA-F1-6177	STAD	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.3056
p.E367K	TCGA-GS-A9TU	DLBC	TCGA	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.0833
p.S301R	DO5452	BRCA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.S304L	DO223732	CESC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7667
p.S304L	DO47368	SKCM	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7667
p.E294K	DO219913	DLBC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1111
p.P314H	DO233271	GACA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1944
p.V372F	DO13024	GBM	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.2222
p.D303E	DO229026	LICA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.6758
p.F302V	DO24606	LUAD	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7068
p.S379F	DO26444	LUSC	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.7982
p.S379F	ACH-000788	Skin Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.7982
p.S379F	A2058	skin	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.7982
p.S301I	DO50099	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.T312S	DO45488	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.25
p.P297R	DO27445	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.1944
p.S392L	DO220875	MELA	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.0556
p.S392F	DO220875	MELA	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.0556
p.S370I	DO51407	PRAD	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1667
p.S309F	DO37782	SKCM	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7982
p.I310V	DO38727	STAD	ICGC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.3056
p.S370N	DO38707	STAD	ICGC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1667
p.R319C	SIDM02021	Esophageal Carcinoma	GDSC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.0556
p.V379I	SIDM00652	Small Cell Lung Carcinoma	GDSC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.5965
p.V379I	NCI-H1105	lung	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.5965
p.R300H	SIDM00596	Endometrial Carcinoma	GDSC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.R300H	HEC-1	endometrium	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation rewiring degron network	0.2778
p.D376N	SIDM01619	Endometrial Carcinoma	GDSC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation altering degron motif	0.6932
p.D369H	ACH-000348	Skin Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1389
p.D369H	RPMI-7951	skin	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1389
p.V306I	ACH-000780	Lung Cancer	CCLE	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7076
p.V306I	NCI-H1105	lung	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.7076
p.N390S	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1111
p.D303N	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSTTPETT	DEG_SCF_FBW7_1	302:309	Mutation altering degron motif	0.6932
p.L384P	NCI-H630	large intestine	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.2778
p.S388L	ESO51	oesophagus	COSMIC	DSGVSSS	DEG_SCF_TRCP1_1	376:382	Mutation rewiring degron network	0.1667

Kaplan plot for ZBTB20 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB20

UniProt ID: Q9HC78

Entrez ID: 26137

Protein name: Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZBTB20 in