DegronMD

Uniprot ID: Q9HC78

Source protein: Zinc finger and BTB domain-containing protein 20

Source gene: ZBTB20

Class: DEG_SCF_FBW7_1

Location: 302:309

E3 ligase: FBXW7

DEGRON score: 0.6311

ASA_SCORE: 89.5625

COIL: 0.8864

CONS_SCORE: 0.5624

DSS_SCORE: 0.6356

HELIX: 0.0373

FCONS_SCORE: 0.9447

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E293A	TCGA-78-7155	LUAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	0.0833
p.R294H	TCGA-A5-A0GB	UCEC	TCGA	LSTTPETT	DEG_SCF_FBW7_1	0.1111
p.R300C	TCGA-AB-2854	LAML	TCGA	LSTTPETT	DEG_SCF_FBW7_1	0.2778
p.R300C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LSTTPETT	DEG_SCF_FBW7_1	0.2778
p.R300C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	0.2778
p.E307K	TCGA-AM-5820	COAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	0.591
p.R294C	TCGA-CD-A4MG	STAD	TCGA	LSTTPETT	DEG_SCF_FBW7_1	0.1111
p.S301R	DO5452	BRCA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.3056
p.S304L	DO223732	CESC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.7667
p.S304L	DO47368	SKCM	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.7667
p.E294K	DO219913	DLBC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.1111
p.P314H	DO233271	GACA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.1944
p.D303E	DO229026	LICA	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.6758
p.F302V	DO24606	LUAD	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.7068
p.S301I	DO50099	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.3056
p.T312S	DO45488	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.25
p.P297R	DO27445	LUSC	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.1944
p.S309F	DO37782	SKCM	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.7982
p.I310V	DO38727	STAD	ICGC	LSTTPETT	DEG_SCF_FBW7_1	0.3056
p.R319C	SIDM02021	Esophageal Carcinoma	GDSC	LSTTPETT	DEG_SCF_FBW7_1	0.0556
p.R300H	SIDM00596	Endometrial Carcinoma	GDSC	LSTTPETT	DEG_SCF_FBW7_1	0.2778
p.R300H	HEC-1	endometrium	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	0.2778
p.V306I	ACH-000780	Lung Cancer	CCLE	LSTTPETT	DEG_SCF_FBW7_1	0.7076
p.V306I	NCI-H1105	lung	COSMIC	LSTTPETT	DEG_SCF_FBW7_1	0.7076
p.D303N	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSTTPETT	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC78	Zinc finger and BTB domain-containing protein 20	DEG_SCF_FBW7_1	302:309	LSTTPETT	FBXW7	0.6311	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons