DegronMD

Uniprot ID: Q8WYP3

Source protein: Ras and Rab interactor 2

Source gene: RIN2

Class: DEG_SCF_TRCP1_1

Location: 74:79

E3 ligase: BTRC

DEGRON score: 0.9952

ASA_SCORE: 82.4333

COIL: 0.8767

CONS_SCORE: 0.509

DSS_SCORE: 0.2896

HELIX: 0.0932

FCONS_SCORE: 1.1985

RIG_SCORE: 0.7388

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S65R	TCGA-AP-A1DV	UCEC	TCGA	DSGYDS	DEG_SCF_TRCP1_1	0.0833
p.V89A	TCGA-G4-6588	COAD	TCGA	DSGYDS	DEG_SCF_TRCP1_1	0.0556
p.T87R	TCGA-UE-A6QU	SARC	TCGA	DSGYDS	DEG_SCF_TRCP1_1	0.1111
p.E66Q	DO2020	BRCA	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.1111
p.Y77C	DO15286	HNSC	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.7087
p.R89L	DO228971	LICA	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.0556
p.R89L	DO229032	LICA	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.0556
p.A72S	DO229038	LICA	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.2778
p.S81Y	DO37431	SKCM	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.2778
p.D88V	DO41355	UCEC	ICGC	DSGYDS	DEG_SCF_TRCP1_1	0.0833
p.R73W	LS-180	large_intestine	COSMIC	DSGYDS	DEG_SCF_TRCP1_1	0.3056
p.D78Y	NCI-H1648	lung	COSMIC	DSGYDS	DEG_SCF_TRCP1_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYP3	Ras and Rab interactor 2	DEG_SCF_TRCP1_1	74:79	DSGYDS	BTRC	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons