DegronMD

Uniprot ID: Q6ZMQ8

Source protein: Serine/threonine-protein kinase LMTK1

Source gene: AATK

Class: DEG_SCF_TRCP1_1

Location: 936:941

E3 ligase: BTRC

DEGRON score: 0.9981

ASA_SCORE: 56.5333

COIL: 0.8

CONS_SCORE: 0.5308

DSS_SCORE: 0.6926

HELIX: 0.1168

FCONS_SCORE: 1.1068

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R933G	TCGA-69-7978	LUAD	TCGA	DSGYDT	DEG_SCF_TRCP1_1	0.25
p.R933G	DO24920	LUAD	ICGC	DSGYDT	DEG_SCF_TRCP1_1	0.25
p.R933L	TCGA-A3-A6NL	KIRC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	0.25
p.A934V	TCGA-AP-A059	UCEC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	0.2778
p.A934V	ACH-002046	Endometrial/Uterine Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	0.2778
p.Y939H	TCGA-BG-A222	UCEC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	0.6118
p.Q931K	DO229029	LICA	ICGC	DSGYDT	DEG_SCF_TRCP1_1	0.1944
p.V940F	DO23334	LINC	ICGC	DSGYDT	DEG_SCF_TRCP1_1	0.7068
p.E942K	SIDM00837	Colorectal Carcinoma	GDSC	DSGYDT	DEG_SCF_TRCP1_1	0.3056
p.E942K	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	0.3056
p.E942K	SW48	large_intestine	COSMIC	DSGYDT	DEG_SCF_TRCP1_1	0.3056
p.G938V	SIDM01480	Ovarian Carcinoma	GDSC	DSGYDT	DEG_SCF_TRCP1_1	0.7532
p.G938V	ACH-000256	Ovarian Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	0.7532
p.P930L	KP-3	pancreas	COSMIC	DSGYDT	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	DEG_SCF_TRCP1_1	936:941	DSGYDT	BTRC	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons