DegronMD - Q6ZMQ8(AATK)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R933G	TCGA-69-7978	LUAD	TCGA	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.25
p.R933G	DO24920	LUAD	ICGC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.25
p.R933L	TCGA-A3-A6NL	KIRC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.25
p.A934V	TCGA-AP-A059	UCEC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.2778
p.A934V	ACH-002046	Endometrial/Uterine Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.2778
p.Y939H	TCGA-BG-A222	UCEC	TCGA	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation altering degron motif	0.6118
p.S1074W	TCGA-BH-A5IZ	BRCA	TCGA	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7874
p.S1074W	DO219607	BRCA	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7874
p.A755V	TCGA-D1-A15X	UCEC	TCGA	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1944
p.A755V	DO43274	UCEC	ICGC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1944
p.P1086L	TCGA-GN-A4U4	SKCM	TCGA	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.P1086L	DO51256	SKCM	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.P1086S	TCGA-GN-A4U4	SKCM	TCGA	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.P709H	TCGA-MN-A4N4	LUAD	TCGA	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.P709H	DO26250	LUAD	ICGC	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.S1076N	DO49095	COAD	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7069
p.A1152T	DO222755	COCA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.3056
p.L1076P	DO233168	GACA	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.6471
p.S1074L	DO233240	GACA	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7667
p.S1074L	ACH-002039	Pancreatic Cancer	CCLE	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7667
p.D770N	DO228943	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.2222
p.Q931K	DO229029	LICA	ICGC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.1944
p.T771K	DO229028	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1944
p.S773R	DO229027	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1389
p.V940F	DO23334	LINC	ICGC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation altering degron motif	0.7068
p.P1136T	DO222494	MELA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.D774N	DO38336	STAD	ICGC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1111
p.L1154M	DO229180	THCA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.25
p.A717V	DO229181	THCA	ICGC	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.5825
p.C1072G	DO229232	THCA	ICGC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.6489
p.E720K	SIDM01298	Esophageal Carcinoma	GDSC	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.2778
p.G772R	SIDM01141	Ovarian Carcinoma	GDSC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.G772R	ACH-000291	Ovarian Cancer	CCLE	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.R1090W	SIDM00499	Prostate Carcinoma	GDSC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.0556
p.P1158L	SIDM00266	Ewing's Sarcoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.P1158L	SIDM01088	Endometrial Carcinoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.P1158L	ACH-000965	Endometrial/Uterine Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.P1158L	ACH-002103	Bone Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.P1158L	RL95-2	endometrium	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.P1158L	ES1	bone	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.S1070I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7341
p.S1070I	ACH-002256	Leukemia	CCLE	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7341
p.S1070I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.7341
p.G1064R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.G1064R	ACH-002256	Leukemia	CCLE	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.G1064R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667
p.P1148S	SIDM00856	Other Solid Cancers	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.5641
p.P1148S	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.5641
p.E942K	SIDM00837	Colorectal Carcinoma	GDSC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.3056
p.E942K	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.3056
p.E942K	SW48	large intestine	COSMIC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.3056
p.R1144H	SIDM00217	Colorectal Carcinoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.8244
p.R1144H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.8244
p.R1144H	SNU-1040	large intestine	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.8244
p.G1149D	SIDM00257	Neuroblastoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation altering degron motif	0.6087
p.A705T	SIDM01608	Endometrial Carcinoma	GDSC	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation rewiring degron network	0.1667
p.H775N	SIDM01617	Endometrial Carcinoma	GDSC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0833
p.H775N	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0833
p.G938V	SIDM01480	Ovarian Carcinoma	GDSC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation altering degron motif	0.7532
p.G938V	ACH-000256	Ovarian Cancer	CCLE	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation altering degron motif	0.7532
p.P1136Q	ACH-000698	Lung Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1389
p.A717T	ACH-000925	Lung Cancer	CCLE	PKQTPRAS	DEG_SCF_FBW7_1	711:718	Mutation altering degron motif	0.6028
p.G1135A	ACH-000985	Colon/Colorectal Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.1111
p.P930L	KP-3	pancreas	COSMIC	DSGYDT	DEG_SCF_TRCP1_1	936:941	Mutation rewiring degron network	0.1667
p.A761D	SNU-407	large intestine	COSMIC	LVTPSWT	DEG_SCF_FBW7_1	760:766	Mutation altering degron motif	0.7793
p.E1079Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation altering degron motif	0.6744
p.F1140S	OCUB-M	breast	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	1143:1151	Mutation rewiring degron network	0.25
p.E1086K	MCC13	skin	COSMIC	STCPSGLVPEP	DEG_COP1_1	1070:1080	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AATK

UniProt ID: Q6ZMQ8

Entrez ID: 9625

Protein name: Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AATK in