DegronMD

Uniprot ID: Q6ZMQ8

Source protein: Serine/threonine-protein kinase LMTK1

Source gene: AATK

Class: DEG_SCF_FBW7_1

Location: 760:766

E3 ligase: FBXW7

DEGRON score: 0.5595

ASA_SCORE: 63.8571

COIL: 0.674

CONS_SCORE: 0.4239

DSS_SCORE: 0.4531

HELIX: 0.2444

FCONS_SCORE: 1.123

RIG_SCORE: 0.7369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A755V	TCGA-D1-A15X	UCEC	TCGA	LVTPSWT	DEG_SCF_FBW7_1	0.1944
p.A755V	DO43274	UCEC	ICGC	LVTPSWT	DEG_SCF_FBW7_1	0.1944
p.D770N	DO228943	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	0.2222
p.T771K	DO229028	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	0.1944
p.S773R	DO229027	LICA	ICGC	LVTPSWT	DEG_SCF_FBW7_1	0.1389
p.D774N	DO38336	STAD	ICGC	LVTPSWT	DEG_SCF_FBW7_1	0.1111
p.G772R	SIDM01141	Ovarian Carcinoma	GDSC	LVTPSWT	DEG_SCF_FBW7_1	0.1667
p.G772R	ACH-000291	Ovarian Cancer	CCLE	LVTPSWT	DEG_SCF_FBW7_1	0.1667
p.H775N	SIDM01617	Endometrial Carcinoma	GDSC	LVTPSWT	DEG_SCF_FBW7_1	0.0833
p.H775N	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVTPSWT	DEG_SCF_FBW7_1	0.0833
p.A761D	SNU-407	large_intestine	COSMIC	LVTPSWT	DEG_SCF_FBW7_1	0.7793

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	DEG_SCF_FBW7_1	760:766	LVTPSWT	FBXW7	0.5595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons