DegronMD

Uniprot ID: Q6ZMQ8

Source protein: Serine/threonine-protein kinase LMTK1

Source gene: AATK

Class: DEG_COP1_1

Location: 1070:1080

E3 ligase: COP1

DEGRON score: 0.9696

ASA_SCORE: 78.6545

COIL: 0.9304

CONS_SCORE: 0.386

DSS_SCORE: 0.7539

HELIX: 0.0282

FCONS_SCORE: 1.0035

RIG_SCORE: 0.5623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1074W	TCGA-BH-A5IZ	BRCA	TCGA	STCPSGLVPEP	DEG_COP1_1	0.7874
p.S1074W	DO219607	BRCA	ICGC	STCPSGLVPEP	DEG_COP1_1	0.7874
p.P1086L	TCGA-GN-A4U4	SKCM	TCGA	STCPSGLVPEP	DEG_COP1_1	0.1667
p.P1086L	DO51256	SKCM	ICGC	STCPSGLVPEP	DEG_COP1_1	0.1667
p.P1086S	TCGA-GN-A4U4	SKCM	TCGA	STCPSGLVPEP	DEG_COP1_1	0.1667
p.S1076N	DO49095	COAD	ICGC	STCPSGLVPEP	DEG_COP1_1	0.7069
p.L1076P	DO233168	GACA	ICGC	STCPSGLVPEP	DEG_COP1_1	0.6471
p.S1074L	DO233240	GACA	ICGC	STCPSGLVPEP	DEG_COP1_1	0.7667
p.S1074L	ACH-002039	Pancreatic Cancer	CCLE	STCPSGLVPEP	DEG_COP1_1	0.7667
p.C1072G	DO229232	THCA	ICGC	STCPSGLVPEP	DEG_COP1_1	0.6489
p.R1090W	SIDM00499	Prostate Carcinoma	GDSC	STCPSGLVPEP	DEG_COP1_1	0.0556
p.S1070I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	STCPSGLVPEP	DEG_COP1_1	0.7341
p.S1070I	ACH-002256	Leukemia	CCLE	STCPSGLVPEP	DEG_COP1_1	0.7341
p.S1070I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	0.7341
p.G1064R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	STCPSGLVPEP	DEG_COP1_1	0.1667
p.G1064R	ACH-002256	Leukemia	CCLE	STCPSGLVPEP	DEG_COP1_1	0.1667
p.G1064R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	0.1667
p.E1079Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	STCPSGLVPEP	DEG_COP1_1	0.6744
p.E1086K	MCC13	skin	COSMIC	STCPSGLVPEP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	DEG_COP1_1	1070:1080	STCPSGLVPEP	COP1	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons