DegronMD

Uniprot ID: Q6ZMQ8

Source protein: Serine/threonine-protein kinase LMTK1

Source gene: AATK

Class: DEG_SCF_FBW7_1

Location: 711:718

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 80.15

COIL: 0.8736

CONS_SCORE: 0.4703

DSS_SCORE: 0.7102

HELIX: 0.0338

FCONS_SCORE: 1.348

RIG_SCORE: 0.571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P709H	TCGA-MN-A4N4	LUAD	TCGA	PKQTPRAS	DEG_SCF_FBW7_1	0.2778
p.P709H	DO26250	LUAD	ICGC	PKQTPRAS	DEG_SCF_FBW7_1	0.2778
p.A717V	DO229181	THCA	ICGC	PKQTPRAS	DEG_SCF_FBW7_1	0.5825
p.E720K	SIDM01298	Esophageal Carcinoma	GDSC	PKQTPRAS	DEG_SCF_FBW7_1	0.2778
p.A705T	SIDM01608	Endometrial Carcinoma	GDSC	PKQTPRAS	DEG_SCF_FBW7_1	0.1667
p.A717T	ACH-000925	Lung Cancer	CCLE	PKQTPRAS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	DEG_SCF_FBW7_1	711:718	PKQTPRAS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons