DegronMD

Uniprot ID: Q6ZMQ8

Source protein: Serine/threonine-protein kinase LMTK1

Source gene: AATK

Class: DEG_APCC_DBOX_1

Location: 1143:1151

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9893

ASA_SCORE: 74.9444

COIL: 0.7761

CONS_SCORE: 0.4462

DSS_SCORE: 0.6913

HELIX: 0.171

FCONS_SCORE: 1.1102

RIG_SCORE: 0.6784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1152T	DO222755	COCA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	0.3056
p.P1136T	DO222494	MELA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.L1154M	DO229180	THCA	ICGC	LRLALPGLP	DEG_APCC_DBOX_1	0.25
p.P1158L	SIDM00266	Ewing's Sarcoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1158L	SIDM01088	Endometrial Carcinoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1158L	ACH-000965	Endometrial/Uterine Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1158L	ACH-002103	Bone Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1158L	RL95-2	endometrium	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1158L	ES1	bone	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.P1148S	SIDM00856	Other Solid Cancers	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.5641
p.P1148S	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.5641
p.R1144H	SIDM00217	Colorectal Carcinoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.8244
p.R1144H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	0.8244
p.R1144H	SNU-1040	large_intestine	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	0.8244
p.G1149D	SIDM00257	Neuroblastoma	GDSC	LRLALPGLP	DEG_APCC_DBOX_1	0.6087
p.P1136Q	ACH-000698	Lung Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	0.1389
p.G1135A	ACH-000985	Colon/Colorectal Cancer	CCLE	LRLALPGLP	DEG_APCC_DBOX_1	0.1111
p.F1140S	OCUB-M	breast	COSMIC	LRLALPGLP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	DEG_APCC_DBOX_1	1143:1151	LRLALPGLP	APC,CDC20,FZR1	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons