DegronMD

Uniprot ID: Q3KR16

Source protein: Pleckstrin homology domain-containing family G member 6

Source gene: PLEKHG6

Class: DEG_SCF_TRCP1_1

Location: 587:592

E3 ligase: BTRC

DEGRON score: 0.9513

ASA_SCORE: 84.3833

COIL: 0.9262

CONS_SCORE: 0.4304

DSS_SCORE: 0.6867

HELIX: 0.045

FCONS_SCORE: 1.0564

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D577N	TCGA-A8-A094	BRCA	TCGA	DSGYGT	DEG_SCF_TRCP1_1	0.0556
p.D577N	DO2593	BRCA	ICGC	DSGYGT	DEG_SCF_TRCP1_1	0.0556
p.V581A	TCGA-AA-3947	COAD	TCGA	DSGYGT	DEG_SCF_TRCP1_1	0.1667
p.V581A	DO8192	COAD	ICGC	DSGYGT	DEG_SCF_TRCP1_1	0.1667
p.D584Y	DO222884	COCA	ICGC	DSGYGT	DEG_SCF_TRCP1_1	0.25
p.S588Y	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGYGT	DEG_SCF_TRCP1_1	0.712
p.S588Y	ACH-000891	Lung Cancer	CCLE	DSGYGT	DEG_SCF_TRCP1_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR16	Pleckstrin homology domain-containing family G member 6	DEG_SCF_TRCP1_1	587:592	DSGYGT	BTRC	0.9513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons