DegronMD - Q3KR16(PLEKHG6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D577N	TCGA-A8-A094	BRCA	TCGA	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation rewiring degron network	0.0556
p.D577N	DO2593	BRCA	ICGC	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation rewiring degron network	0.0556
p.V581A	TCGA-AA-3947	COAD	TCGA	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation rewiring degron network	0.1667
p.V581A	DO8192	COAD	ICGC	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation rewiring degron network	0.1667
p.S603P	TCGA-AB-2833	LAML	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5641
p.S603P	DO21679	LAML	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5641
p.R618H	TCGA-AC-A8OP	BRCA	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.R618H	TCGA-EO-A22U	UCEC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.R618H	DO50032	BRCA	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.R618H	DO43755	UCEC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.A554T	TCGA-AX-A1C9	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A554T	TCGA-B5-A3FC	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A554T	TCGA-EO-A22R	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A554T	DO43098	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A554T	DO41871	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A554T	DO42713	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.R607H	TCGA-AX-A1CE	UCEC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.7133
p.R607H	DO42280	UCEC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.7133
p.S606R	TCGA-CK-4951	COAD	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.6316
p.S606R	DO10582	COAD	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.6316
p.G600R	TCGA-DX-AB2E	SARC	TCGA	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.G600R	TCGA-GF-A6C8	SKCM	TCGA	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.G600R	DO222868	MELA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.G600R	DO222875	MELA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.G600R	DO220073	SARC	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.G600R	DO48765	SKCM	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.6457
p.R602L	TCGA-DX-AB3C	SARC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.8428
p.R602L	DO220114	SARC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.8428
p.R535M	TCGA-EE-A2MM	SKCM	TCGA	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1389
p.R535M	TCGA-EE-A2MM	SKCM	TCGA	LTLYRD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.R535M	DO37770	SKCM	ICGC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1389
p.R535M	DO37770	SKCM	ICGC	LTLYRD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.25
p.R614W	TCGA-F7-A624	HNSC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.R614W	DO44440	HNSC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.E548K	TCGA-FW-A3R5	SKCM	TCGA	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.7022
p.E548K	DO37406	SKCM	ICGC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.7022
p.D584Y	DO222884	COCA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation rewiring degron network	0.0556
p.D584Y	DO222884	COCA	ICGC	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation rewiring degron network	0.25
p.R614L	DO229019	LICA	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.S539N	SIDM02059	Colorectal Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.25
p.S539N	SIDM02059	Colorectal Carcinoma	GDSC	LTLYRD	LIG_APCC_ABBA_1	527:532	Mutation rewiring degron network	0.1389
p.R609C	SIDM00509	Small Cell Lung Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R609C	SIDM00717	Non-Cancerous	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R609C	SIDM00259	Neuroblastoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R609C	SIDM00476	Ovarian Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R609C	SIDM00420	Bladder Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R609C	SIDM01491	Colorectal Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.P542S	SIDM00629	Breast Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.6752
p.P542S	SIDM01191	Osteosarcoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.6752
p.P542S	SIDM00220	Ovarian Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.6752
p.T544M	SIDM00214	Colorectal Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.8534
p.T544M	ACH-000955	Colon/Colorectal Cancer	CCLE	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.8534
p.T544M	SNU-407	large intestine	COSMIC	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation altering degron motif	0.8534
p.S588Y	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation altering degron motif	0.712
p.S588Y	ACH-000891	Lung Cancer	CCLE	DSGYGT	DEG_SCF_TRCP1_1	587:592	Mutation altering degron motif	0.712
p.R615Q	SIDM01451	Pancreatic Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.R615Q	ACH-000933	Pancreatic Cancer	CCLE	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.A554V	ACH-001407	Bladder Cancer	CCLE	PSTPSLE	DEG_SCF_FBW7_2	542:548	Mutation rewiring degron network	0.1667
p.A614V	SNU-407	large intestine	COSMIC	SRSPLSRLR	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.R600H	GP5d	large intestine	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.8244
p.R595W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.8634
p.I597T	SNU-1040	large intestine	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	594:601	Mutation altering degron motif	0.7078
p.S530L	NB14	autonomic ganglia	COSMIC	LTLYRD	LIG_APCC_ABBA_1	527:532	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG6

UniProt ID: Q3KR16

Entrez ID: 55200

Protein name: Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG6 in