DegronMD

Uniprot ID: Q3KR16

Source protein: Pleckstrin homology domain-containing family G member 6

Source gene: PLEKHG6

Class: DEG_SCF_FBW7_2

Location: 542:548

E3 ligase: FBXW7

DEGRON score: 0.9541

ASA_SCORE: 95.3286

COIL: 0.9219

CONS_SCORE: 0.3736

DSS_SCORE: 0.8128

HELIX: 0.037

FCONS_SCORE: 0.978

RIG_SCORE: 0.5609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A554T	TCGA-AX-A1C9	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.A554T	TCGA-B5-A3FC	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.A554T	TCGA-EO-A22R	UCEC	TCGA	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.A554T	DO43098	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.A554T	DO41871	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.A554T	DO42713	UCEC	ICGC	PSTPSLE	DEG_SCF_FBW7_2	0.1667
p.R535M	TCGA-EE-A2MM	SKCM	TCGA	PSTPSLE	DEG_SCF_FBW7_2	0.1389
p.R535M	DO37770	SKCM	ICGC	PSTPSLE	DEG_SCF_FBW7_2	0.1389
p.E548K	TCGA-FW-A3R5	SKCM	TCGA	PSTPSLE	DEG_SCF_FBW7_2	0.7022
p.E548K	DO37406	SKCM	ICGC	PSTPSLE	DEG_SCF_FBW7_2	0.7022
p.S539N	SIDM02059	Colorectal Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	0.25
p.P542S	SIDM00629	Breast Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	0.6752
p.P542S	SIDM01191	Osteosarcoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	0.6752
p.P542S	SIDM00220	Ovarian Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	0.6752
p.T544M	SIDM00214	Colorectal Carcinoma	GDSC	PSTPSLE	DEG_SCF_FBW7_2	0.8534
p.T544M	ACH-000955	Colon/Colorectal Cancer	CCLE	PSTPSLE	DEG_SCF_FBW7_2	0.8534
p.T544M	SNU-407	large_intestine	COSMIC	PSTPSLE	DEG_SCF_FBW7_2	0.8534
p.A554V	ACH-001407	Bladder Cancer	CCLE	PSTPSLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR16	Pleckstrin homology domain-containing family G member 6	DEG_SCF_FBW7_2	542:548	PSTPSLE	FBXW7	0.9541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons