DegronMD

Uniprot ID: Q3KR16

Source protein: Pleckstrin homology domain-containing family G member 6

Source gene: PLEKHG6

Class: DEG_SCF_FBW7_1

Location: 594:601

E3 ligase: FBXW7

DEGRON score: 0.9749

ASA_SCORE: 81.475

COIL: 0.9545

CONS_SCORE: 0.3999

DSS_SCORE: 0.6631

HELIX: 0.0159

FCONS_SCORE: 0.9773

RIG_SCORE: 0.6183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G600R	TCGA-DX-AB2E	SARC	TCGA	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.G600R	TCGA-GF-A6C8	SKCM	TCGA	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.G600R	DO222868	MELA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.G600R	DO222875	MELA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.G600R	DO220073	SARC	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.G600R	DO48765	SKCM	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	0.6457
p.D584Y	DO222884	COCA	ICGC	IPGTPTGS	DEG_SCF_FBW7_1	0.0556
p.R600H	GP5d	large_intestine	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	0.8244
p.R595W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	0.8634
p.I597T	SNU-1040	large_intestine	COSMIC	IPGTPTGS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR16	Pleckstrin homology domain-containing family G member 6	DEG_SCF_FBW7_1	594:601	IPGTPTGS	FBXW7	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons