DegronMD

Uniprot ID: Q3KR16

Source protein: Pleckstrin homology domain-containing family G member 6

Source gene: PLEKHG6

Class: LIG_APCC_ABBA_1

Location: 527:532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9238

ASA_SCORE: 110.1333

COIL: 0.4308

CONS_SCORE: 0.2927

DSS_SCORE: 0.5757

HELIX: 0.5513

FCONS_SCORE: 0.9815

RIG_SCORE: 0.7818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535M	TCGA-EE-A2MM	SKCM	TCGA	LTLYRD	LIG_APCC_ABBA_1	0.25
p.R535M	DO37770	SKCM	ICGC	LTLYRD	LIG_APCC_ABBA_1	0.25
p.S539N	SIDM02059	Colorectal Carcinoma	GDSC	LTLYRD	LIG_APCC_ABBA_1	0.1389
p.S530L	NB14	autonomic_ganglia	COSMIC	LTLYRD	LIG_APCC_ABBA_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR16	Pleckstrin homology domain-containing family G member 6	LIG_APCC_ABBA_1	527:532	LTLYRD	APC,CDC20,FZR1	0.9238	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons