DegronMD

Uniprot ID: Q3KR16

Source protein: Pleckstrin homology domain-containing family G member 6

Source gene: PLEKHG6

Class: DEG_APCC_DBOX_1

Location: 601:609

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7807

ASA_SCORE: 108.7333

COIL: 0.735

CONS_SCORE: 0.3845

DSS_SCORE: 0.6652

HELIX: 0.2407

FCONS_SCORE: 0.9716

RIG_SCORE: 0.6932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S603P	TCGA-AB-2833	LAML	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.5641
p.S603P	DO21679	LAML	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.5641
p.R618H	TCGA-AC-A8OP	BRCA	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.0833
p.R618H	TCGA-EO-A22U	UCEC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.0833
p.R618H	DO50032	BRCA	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.0833
p.R618H	DO43755	UCEC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.0833
p.R607H	TCGA-AX-A1CE	UCEC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.7133
p.R607H	DO42280	UCEC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.7133
p.S606R	TCGA-CK-4951	COAD	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.6316
p.S606R	DO10582	COAD	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.6316
p.R602L	TCGA-DX-AB3C	SARC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.8428
p.R602L	DO220114	SARC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.8428
p.R614W	TCGA-F7-A624	HNSC	TCGA	SRSPLSRLR	DEG_APCC_DBOX_1	0.1944
p.R614W	DO44440	HNSC	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.1944
p.R614L	DO229019	LICA	ICGC	SRSPLSRLR	DEG_APCC_DBOX_1	0.1944
p.R609C	SIDM00509	Small Cell Lung Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R609C	SIDM00717	Non-Cancerous	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R609C	SIDM00259	Neuroblastoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R609C	SIDM00476	Ovarian Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R609C	SIDM00420	Bladder Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R609C	SIDM01491	Colorectal Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.719
p.R615Q	SIDM01451	Pancreatic Carcinoma	GDSC	SRSPLSRLR	DEG_APCC_DBOX_1	0.1667
p.R615Q	ACH-000933	Pancreatic Cancer	CCLE	SRSPLSRLR	DEG_APCC_DBOX_1	0.1667
p.A614V	SNU-407	large_intestine	COSMIC	SRSPLSRLR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR16	Pleckstrin homology domain-containing family G member 6	DEG_APCC_DBOX_1	601:609	SRSPLSRLR	APC,CDC20,FZR1	0.7807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSPLSRLR

Degron related mutations and impact score

Drug responses associated with PLEKHG6 mutations

All proteins holding degron of SRSPLSRLR