DegronMD

Uniprot ID: Q16649

Source protein: Nuclear factor interleukin-3-regulated protein

Source gene: NFIL3

Class: DEG_SCF_TRCP1_1

Location: 420:426

E3 ligase: BTRC

DEGRON score: 0.9927

ASA_SCORE: 77.0857

COIL: 0.8113

CONS_SCORE: 0.4357

DSS_SCORE: 0.3454

HELIX: 0.0771

FCONS_SCORE: 1.0007

RIG_SCORE: 0.7449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D427V	TCGA-12-1089	GBM	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	0.3056
p.D427V	DO12346	GBM	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	0.3056
p.M418L	TCGA-55-8621	LUAD	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	0.2778
p.M418L	DO25406	LUAD	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	0.2778
p.E429D	TCGA-AN-A046	BRCA	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	0.25
p.E429D	DO1285	BRCA	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	0.25
p.Y432C	TCGA-UF-A7JF	HNSC	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	0.1667
p.Y432C	DO52116	HNSC	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	0.1667
p.V425D	ACH-002289	Leukemia	CCLE	DSGYKVS	DEG_SCF_TRCP1_1	0.6674
p.V425D	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYKVS	DEG_SCF_TRCP1_1	0.6674

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16649	Nuclear factor interleukin-3-regulated protein	DEG_SCF_TRCP1_1	420:426	DSGYKVS	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons