DegronMD - Q16649(NFIL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D427V	TCGA-12-1089	GBM	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.3056
p.D427V	DO12346	GBM	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.3056
p.G249R	TCGA-16-1045	GBM	TCGA	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.3056
p.G249R	DO11800	GBM	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.3056
p.M418L	TCGA-55-8621	LUAD	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.2778
p.M418L	DO25406	LUAD	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.2778
p.E429D	TCGA-AN-A046	BRCA	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.25
p.E429D	DO1285	BRCA	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.25
p.A241V	TCGA-AX-A1CE	UCEC	TCGA	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.0833
p.A241V	DO42280	UCEC	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.0833
p.S251Y	TCGA-BS-A0TC	UCEC	TCGA	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.6009
p.S251Y	DO42400	UCEC	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.6009
p.S253F	TCGA-IB-7651	PAAD	TCGA	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.6871
p.S253F	DO46657	PAAD	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.6871
p.T240A	TCGA-ND-A4WC	UCS	TCGA	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.0556
p.Y432C	TCGA-UF-A7JF	HNSC	TCGA	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.1667
p.Y432C	DO52116	HNSC	ICGC	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation rewiring degron network	0.1667
p.L262M	DO229032	LICA	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation rewiring degron network	0.25
p.H257D	DO46424	OV	ICGC	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.6577
p.F252L	SIDM00193	Colorectal Carcinoma	GDSC	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.587
p.F252L	ACH-000991	Colon/Colorectal Cancer	CCLE	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.587
p.F252L	SNU-81	large intestine	COSMIC	NSFSGYSHSP	CBL_PTK	250:259	Mutation altering degron motif	0.587
p.V425D	ACH-002289	Leukemia	CCLE	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation altering degron motif	0.6674
p.V425D	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	DSGYKVS	DEG_SCF_TRCP1_1	420:426	Mutation altering degron motif	0.6674

Kaplan plot for NFIL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFIL3

UniProt ID: Q16649

Entrez ID: 4783

Protein name: Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFIL3 in