DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NSFSGYSHSP
Uniprot ID:
Q16649
Source protein:
Nuclear factor interleukin-3-regulated protein
Source gene:
NFIL3
Class:
CBL_PTK
Location:
250:259
E3 ligase:
CBL
DEGRON score:
0.9161
ASA_SCORE:
59.8
COIL:
0.8582
CONS_SCORE:
0.3878
DSS_SCORE:
0.4877
HELIX:
0.0571
FCONS_SCORE:
0.9208
RIG_SCORE:
0.6468
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G249R
TCGA-16-1045
GBM
TCGA
NSFSGYSHSP
CBL_PTK
0.3056
p.G249R
DO11800
GBM
ICGC
NSFSGYSHSP
CBL_PTK
0.3056
p.A241V
TCGA-AX-A1CE
UCEC
TCGA
NSFSGYSHSP
CBL_PTK
0.0833
p.A241V
DO42280
UCEC
ICGC
NSFSGYSHSP
CBL_PTK
0.0833
p.S251Y
TCGA-BS-A0TC
UCEC
TCGA
NSFSGYSHSP
CBL_PTK
0.6009
p.S251Y
DO42400
UCEC
ICGC
NSFSGYSHSP
CBL_PTK
0.6009
p.S253F
TCGA-IB-7651
PAAD
TCGA
NSFSGYSHSP
CBL_PTK
0.6871
p.S253F
DO46657
PAAD
ICGC
NSFSGYSHSP
CBL_PTK
0.6871
p.T240A
TCGA-ND-A4WC
UCS
TCGA
NSFSGYSHSP
CBL_PTK
0.0556
p.L262M
DO229032
LICA
ICGC
NSFSGYSHSP
CBL_PTK
0.25
p.H257D
DO46424
OV
ICGC
NSFSGYSHSP
CBL_PTK
0.6577
p.F252L
SIDM00193
Colorectal Carcinoma
GDSC
NSFSGYSHSP
CBL_PTK
0.587
p.F252L
ACH-000991
Colon/Colorectal Cancer
CCLE
NSFSGYSHSP
CBL_PTK
0.587
p.F252L
SNU-81
large_intestine
COSMIC
NSFSGYSHSP
CBL_PTK
0.587
Drug responses associated with NFIL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSFSGYSHSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16649
Nuclear factor interleukin-3-regulated protein
CBL_PTK
250:259
NSFSGYSHSP
CBL
0.9161
More...
