DegronMD

Uniprot ID: O00418

Source protein: Eukaryotic elongation factor 2 kinase

Source gene: EEF2K

Class: DEG_SCF_TRCP1_1

Location: 440:445

E3 ligase: BTRC

DEGRON score: 0.9983

ASA_SCORE: 63.2

COIL: 0.853

CONS_SCORE: 0.287

DSS_SCORE: 0.7649

HELIX: 0.1055

FCONS_SCORE: 1.0339

RIG_SCORE: 0.5016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E436D	TCGA-CA-6718	COAD	TCGA	DSGYPS	DEG_SCF_TRCP1_1	0.2222
p.E436D	DO7801	COAD	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.2222
p.N431Y	TCGA-CN-5356	HNSC	TCGA	DSGYPS	DEG_SCF_TRCP1_1	0.0833
p.N431Y	DO15390	HNSC	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.0833
p.R448L	TCGA-G2-A2EJ	BLCA	TCGA	DSGYPS	DEG_SCF_TRCP1_1	0.25
p.R448L	DO554	BLCA	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.25
p.R433L	DO230342	COCA	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.1389
p.H432L	DO234336	ESAD	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.1111
p.S438I	DO229036	LICA	ICGC	DSGYPS	DEG_SCF_TRCP1_1	0.7222
p.S438N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGYPS	DEG_SCF_TRCP1_1	0.7222
p.S438N	ACH-000981	Leukemia	CCLE	DSGYPS	DEG_SCF_TRCP1_1	0.7222
p.S438N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYPS	DEG_SCF_TRCP1_1	0.7222
p.G449S	SIDM00196	Ewing's Sarcoma	GDSC	DSGYPS	DEG_SCF_TRCP1_1	0.2222
p.G449S	EW-22	bone	COSMIC	DSGYPS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00418	Eukaryotic elongation factor 2 kinase	DEG_SCF_TRCP1_1	440:445	DSGYPS	BTRC	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons