DegronMD

Uniprot ID: Q9Y2T1

Source protein: Axin-2

Source gene: AXIN2

Class: DEG_SCF_TRCP1_1

Location: 268:273

E3 ligase: BTRC

DEGRON score: 0.9779

ASA_SCORE: 73.45

COIL: 0.7548

CONS_SCORE: 0.4117

DSS_SCORE: 0.4323

HELIX: 0.1738

FCONS_SCORE: 1.0444

RIG_SCORE: 0.7503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T264M	TCGA-32-1970	GBM	TCGA	DSGYRS	DEG_SCF_TRCP1_1	0.2222
p.T264M	DO13144	GBM	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.2222
p.D268Y	TCGA-A3-A6NN	KIRC	TCGA	DSGYRS	DEG_SCF_TRCP1_1	0.7325
p.D268Y	DO219230	KIRC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.7325
p.D278N	TCGA-AP-A1DV	UCEC	TCGA	DSGYRS	DEG_SCF_TRCP1_1	0.1944
p.D278N	DO43186	UCEC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.1944
p.K275R	TCGA-EB-A24D	SKCM	TCGA	DSGYRS	DEG_SCF_TRCP1_1	0.2778
p.K275R	DO37440	SKCM	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.2778
p.E265K	TCGA-ZF-A9RC	BLCA	TCGA	DSGYRS	DEG_SCF_TRCP1_1	0.25
p.E265K	DO219068	BLCA	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.25
p.P282H	DO16999	KIRC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.0833
p.P282H	DO42256	UCEC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.0833
p.D268E	DO229037	LICA	ICGC	DSGYRS	DEG_SCF_TRCP1_1	0.6758
p.D268N	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	DSGYRS	DEG_SCF_TRCP1_1	0.6932
p.D268N	ACH-001233	Lung Cancer	CCLE	DSGYRS	DEG_SCF_TRCP1_1	0.6932
p.D268N	VMRC-LCD	lung	COSMIC	DSGYRS	DEG_SCF_TRCP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2T1	Axin-2	DEG_SCF_TRCP1_1	268:273	DSGYRS	BTRC	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons