DegronMD - Q9Y2T1(AXIN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T264M	TCGA-32-1970	GBM	TCGA	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.2222
p.T264M	DO13144	GBM	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.2222
p.D268Y	TCGA-A3-A6NN	KIRC	TCGA	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.7325
p.D268Y	DO219230	KIRC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.7325
p.A695V	TCGA-AP-A059	UCEC	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.A695V	DO41361	UCEC	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.D278N	TCGA-AP-A1DV	UCEC	TCGA	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.1944
p.D278N	DO43186	UCEC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.1944
p.Q681H	TCGA-BG-A222	UCEC	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.K275R	TCGA-EB-A24D	SKCM	TCGA	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.2778
p.K275R	DO37440	SKCM	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.2778
p.F679L	TCGA-EE-A2MG	SKCM	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1389
p.F679L	DO37421	SKCM	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1389
p.T693M	TCGA-RD-A8N6	STAD	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.7423
p.E265K	TCGA-ZF-A9RC	BLCA	TCGA	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.25
p.E265K	DO219068	BLCA	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.25
p.R702C	TCGA-ZF-AA4R	BLCA	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.R702C	DO219083	BLCA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.R702C	SIDM01307	Colorectal Carcinoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0833
p.T693K	DO233885	GACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.7306
p.D682E	DO233847	GACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2222
p.P282H	DO16999	KIRC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.0833
p.P282H	DO42256	UCEC	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation rewiring degron network	0.0833
p.D268E	DO229037	LICA	ICGC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.6758
p.D682G	DO233293	NACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2222
p.A676T	DO46380	OV	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0556
p.D268N	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.6932
p.D268N	ACH-001233	Lung Cancer	CCLE	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.6932
p.D268N	VMRC-LCD	lung	COSMIC	DSGYRS	DEG_SCF_TRCP1_1	268:273	Mutation altering degron motif	0.6932
p.A684V	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.A684V	SIDM01050	Biliary Tract Carcinoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.V691A	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPLTPPNT	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.6936

Kaplan plot for AXIN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AXIN2

UniProt ID: Q9Y2T1

Entrez ID: 8313

Protein name: Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AXIN2 in