DegronMD

Uniprot ID: Q9Y2T1

Source protein: Axin-2

Source gene: AXIN2

Class: DEG_SCF_FBW7_1

Location: 686:693

E3 ligase: FBXW7

DEGRON score: 0.7189

ASA_SCORE: 82.35

COIL: 0.8945

CONS_SCORE: 0.4024

DSS_SCORE: 0.6039

HELIX: 0.0963

FCONS_SCORE: 1.0038

RIG_SCORE: 0.6687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A695V	TCGA-AP-A059	UCEC	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	0.2778
p.A695V	DO41361	UCEC	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.2778
p.Q681H	TCGA-BG-A222	UCEC	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	0.1944
p.F679L	TCGA-EE-A2MG	SKCM	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	0.1389
p.F679L	DO37421	SKCM	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.1389
p.T693M	TCGA-RD-A8N6	STAD	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	0.7423
p.R702C	TCGA-ZF-AA4R	BLCA	TCGA	PPLTPPNT	DEG_SCF_FBW7_1	0.0833
p.R702C	DO219083	BLCA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.0833
p.R702C	SIDM01307	Colorectal Carcinoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	0.0833
p.T693K	DO233885	GACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.7306
p.D682E	DO233847	GACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.2222
p.D682G	DO233293	NACA	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.2222
p.A676T	DO46380	OV	ICGC	PPLTPPNT	DEG_SCF_FBW7_1	0.0556
p.A684V	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	0.2778
p.A684V	SIDM01050	Biliary Tract Carcinoma	GDSC	PPLTPPNT	DEG_SCF_FBW7_1	0.2778
p.V691A	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPLTPPNT	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2T1	Axin-2	DEG_SCF_FBW7_1	686:693	PPLTPPNT	FBXW7	0.7189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons