DegronMD

Uniprot ID: Q9BW30

Source protein: Tubulin polymerization-promoting protein family member 3

Source gene: TPPP3

Class: DEG_SCF_TRCP1_1

Location: 157:162

E3 ligase: BTRC

DEGRON score: 0.984

ASA_SCORE: 57.6167

COIL: 0.785

CONS_SCORE: 0.5297

DSS_SCORE: 0.3044

HELIX: 0.1003

FCONS_SCORE: 1.0771

RIG_SCORE: 0.7774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D157N	TCGA-A6-6781	COAD	TCGA	DSGYVS	DEG_SCF_TRCP1_1	0.6932
p.D157N	DO8447	COAD	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.6932
p.D157N	DO233207	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.6932
p.D171N	TCGA-AP-A1DV	UCEC	TCGA	DSGYVS	DEG_SCF_TRCP1_1	0.0833
p.D171N	DO43186	UCEC	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.0833
p.A163S	TCGA-BH-A0BL	BRCA	TCGA	DSGYVS	DEG_SCF_TRCP1_1	0.3056
p.A163S	DO4275	BRCA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.3056
p.V161M	DO233624	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.6097
p.S162R	DO228948	LICA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.8538
p.A167E	DO229009	LICA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW30	Tubulin polymerization-promoting protein family member 3	DEG_SCF_TRCP1_1	157:162	DSGYVS	BTRC	0.984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons