DegronMD - Q9BW30(TPPP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5825
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5825
p.A18V	DO41235	UCEC	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5825
p.A18V	DO41235	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5825
p.D157N	TCGA-A6-6781	COAD	TCGA	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.D157N	DO8447	COAD	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.D157N	DO233207	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.D171N	TCGA-AP-A1DV	UCEC	TCGA	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0833
p.D171N	DO43186	UCEC	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.0833
p.R15S	TCGA-BF-A1Q0	SKCM	TCGA	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2778
p.R15S	TCGA-BF-A1Q0	SKCM	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.R15S	DO47374	SKCM	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2778
p.R15S	DO47374	SKCM	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.A163S	TCGA-BH-A0BL	BRCA	TCGA	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.A163S	DO4275	BRCA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.R15H	TCGA-EO-A22R	UCEC	TCGA	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2778
p.R15H	TCGA-EO-A22R	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.R15H	DO42713	UCEC	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2778
p.R15H	DO42713	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.P23L	DO233154	GACA	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.P23L	DO233154	GACA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.V161M	DO233624	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6097
p.S162R	DO228948	LICA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.8538
p.A8D	DO228985	LICA	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0833
p.A8D	DO228985	LICA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.1111
p.D22E	DO228985	LICA	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5647
p.D22E	DO228985	LICA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5647
p.A167E	DO229009	LICA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.1944
p.D6N	SIDM00855	Other Sarcomas	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.0556
p.D6N	ACH-000375	Kidney Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.0556
p.D6N	G-402	soft tissue	COSMIC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.0556
p.S26N	SIDM01617	Endometrial Carcinoma	GDSC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.S26N	SIDM01617	Endometrial Carcinoma	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.2222
p.S26N	ACH-000994	Endometrial/Uterine Cancer	CCLE	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.S26N	ACH-000994	Endometrial/Uterine Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.2222
p.A25T	SIDM01447	Glioblastoma	GDSC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.25
p.A25T	SIDM01447	Glioblastoma	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.25
p.P23T	ACH-000460	Ovarian Cancer	CCLE	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.P23T	ACH-000460	Ovarian Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056

Kaplan plot for TPPP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPPP3

UniProt ID: Q9BW30

Entrez ID: 51673

Protein name: Tubulin polymerization-promoting protein family member 3 (TPPP/p20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPPP3 in