DegronMD - Q9BW30(TPPP3)

FUNCTION: Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (PubMed:30667362). {ECO:0000250|UniProtKB:Q9CRB6, ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818, ECO:0000269|PubMed:30667362}.

GO - Biological processes (BP): decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]

GO - Molecular function (MF): tubulin binding [GO:0015631]

GO - Cellular component (CC): cytoplasm [GO:0005737]; microtubule [GO:0005874]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DSGYVS	DEG_SCF_TRCP1_1	BTRC	Tubulin polymerization-promoting protein family member 3	157:162	More..
FAIHGD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Tubulin polymerization-promoting protein family member 3	17:22	More..
KFAIHGD	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	Tubulin polymerization-promoting protein family member 3	16:22	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S162R	DO228948	LICA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.8538
p.D157N	TCGA-A6-6781	COAD	TCGA	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.D157N	DO8447	COAD	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.D157N	DO233207	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6932
p.V161M	DO233624	GACA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation altering degron motif	0.6097
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5825
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5825
p.A18V	DO41235	UCEC	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5825
p.A18V	DO41235	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5825
p.D22E	DO228985	LICA	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.5647
p.D22E	DO228985	LICA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation altering degron motif	0.5647
p.R15S	TCGA-BF-A1Q0	SKCM	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.R15S	DO47374	SKCM	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.A163S	TCGA-BH-A0BL	BRCA	TCGA	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.A163S	DO4275	BRCA	ICGC	DSGYVS	DEG_SCF_TRCP1_1	157:162	Mutation rewiring degron network	0.3056
p.R15H	TCGA-EO-A22R	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.R15H	DO42713	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.P23L	DO233154	GACA	ICGC	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.P23L	DO233154	GACA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	16:22	Mutation rewiring degron network	0.3056
p.P23T	ACH-000460	Ovarian Cancer	CCLE	FAIHGD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPPP3

UniProt ID: Q9BW30

Entrez ID: 51673

Protein name: Tubulin polymerization-promoting protein family member 3 (TPPP/p20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPPP3 in