DegronMD

Uniprot ID: Q9BW30

Source protein: Tubulin polymerization-promoting protein family member 3

Source gene: TPPP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 16:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9225

ASA_SCORE: 55.8

COIL: 0.5181

CONS_SCORE: 0.5286

DSS_SCORE: 0.4426

HELIX: 0.464

FCONS_SCORE: 1.2092

RIG_SCORE: 0.7517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.5825
p.A18V	DO41235	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.5825
p.R15S	TCGA-BF-A1Q0	SKCM	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R15S	DO47374	SKCM	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R15H	TCGA-EO-A22R	UCEC	TCGA	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R15H	DO42713	UCEC	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P23L	DO233154	GACA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A8D	DO228985	LICA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D22E	DO228985	LICA	ICGC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D6N	SIDM00855	Other Sarcomas	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D6N	ACH-000375	Kidney Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D6N	G-402	soft_tissue	COSMIC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S26N	SIDM01617	Endometrial Carcinoma	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S26N	ACH-000994	Endometrial/Uterine Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A25T	SIDM01447	Glioblastoma	GDSC	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.P23T	ACH-000460	Ovarian Cancer	CCLE	KFAIHGD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW30	Tubulin polymerization-promoting protein family member 3	LIG_APCC_ABBAyCdc20_2	16:22	KFAIHGD	APC,CDC20,FZR1	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons