DegronMD

Uniprot ID: Q9BW30

Source protein: Tubulin polymerization-promoting protein family member 3

Source gene: TPPP3

Class: LIG_APCC_ABBA_1

Location: 17:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.808

ASA_SCORE: 49.1833

COIL: 0.6007

CONS_SCORE: 0.5339

DSS_SCORE: 0.4478

HELIX: 0.3792

FCONS_SCORE: 1.1938

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A18V	TCGA-A5-A0G2	UCEC	TCGA	FAIHGD	LIG_APCC_ABBA_1	0.5825
p.A18V	DO41235	UCEC	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.5825
p.R15S	TCGA-BF-A1Q0	SKCM	TCGA	FAIHGD	LIG_APCC_ABBA_1	0.2778
p.R15S	DO47374	SKCM	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.2778
p.R15H	TCGA-EO-A22R	UCEC	TCGA	FAIHGD	LIG_APCC_ABBA_1	0.2778
p.R15H	DO42713	UCEC	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.2778
p.P23L	DO233154	GACA	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.3056
p.A8D	DO228985	LICA	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.0833
p.D22E	DO228985	LICA	ICGC	FAIHGD	LIG_APCC_ABBA_1	0.5647
p.S26N	SIDM01617	Endometrial Carcinoma	GDSC	FAIHGD	LIG_APCC_ABBA_1	0.2222
p.S26N	ACH-000994	Endometrial/Uterine Cancer	CCLE	FAIHGD	LIG_APCC_ABBA_1	0.2222
p.A25T	SIDM01447	Glioblastoma	GDSC	FAIHGD	LIG_APCC_ABBA_1	0.25
p.P23T	ACH-000460	Ovarian Cancer	CCLE	FAIHGD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW30	Tubulin polymerization-promoting protein family member 3	LIG_APCC_ABBA_1	17:22	FAIHGD	APC,CDC20,FZR1	0.808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons