DegronMD

Uniprot ID: Q96JM2

Source protein: Zinc finger protein 462

Source gene: ZNF462

Class: CBL_PTK

Location: 2140:2150

E3 ligase: CBL

DEGRON score: 0.7913

ASA_SCORE: 85.3455

COIL: 0.8005

CONS_SCORE: 0.6451

DSS_SCORE: 0.7627

HELIX: 0.1232

FCONS_SCORE: 1.0939

RIG_SCORE: 0.5946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2143Y	TCGA-09-2044	OV	TCGA	DSNDSSYSEPP	CBL_PTK	0.6214
p.P2134L	TCGA-A5-A0G2	UCEC	TCGA	DSNDSSYSEPP	CBL_PTK	0.1667
p.P2134L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSNDSSYSEPP	CBL_PTK	0.1667
p.P2134L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DSNDSSYSEPP	CBL_PTK	0.1667
p.P2134A	TCGA-CN-A640	HNSC	TCGA	DSNDSSYSEPP	CBL_PTK	0.1667
p.M2153V	DO8151	COAD	ICGC	DSNDSSYSEPP	CBL_PTK	0.25
p.W2147L	DO228952	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	0.7015
p.K2159N	DO228976	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	0.0833
p.G2139C	DO229037	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	0.3056
p.M2153I	DO47819	STAD	ICGC	DSNDSSYSEPP	CBL_PTK	0.25
p.V2152F	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	0.2778
p.V2152F	NCI-H1299	lung	COSMIC	DSNDSSYSEPP	CBL_PTK	0.2778
p.E2136K	SIDM00555	Glioblastoma	GDSC	DSNDSSYSEPP	CBL_PTK	0.2222
p.E2136K	KS-1	central_nervous_system	COSMIC	DSNDSSYSEPP	CBL_PTK	0.2222
p.V2152G	SIDM01037	Breast Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	0.2778
p.V2152G	JIMT-1	breast	COSMIC	DSNDSSYSEPP	CBL_PTK	0.2778
p.E2136G	SIDM00837	Colorectal Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	0.2222
p.E2136G	SW48	large_intestine	COSMIC	DSNDSSYSEPP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM2	Zinc finger protein 462	CBL_PTK	2140:2150	DSNDSSYSEPP	CBL	0.7913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons