DegronMD - Q96JM2(ZNF462)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D2143Y	TCGA-09-2044	OV	TCGA	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation altering degron motif	0.6214
p.Q1471K	TCGA-55-6979	LUAD	TCGA	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.25
p.Q1471K	DO24110	LUAD	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.25
p.E2358Q	TCGA-95-7944	LUAD	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation rewiring degron network	0.25
p.P2134L	TCGA-A5-A0G2	UCEC	TCGA	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.1667
p.P2134L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.1667
p.P2134L	REH	haematopoietic and lymphoid tissue	COSMIC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.1667
p.K2352N	TCGA-B5-A1MX	UCEC	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation substituting flanking lysine	0.1944
p.A1464T	TCGA-B7-A5TI	STAD	TCGA	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation altering degron motif	0.7139
p.A1464T	DO222328	STAD	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation altering degron motif	0.7139
p.A1464T	SIDM02059	Colorectal Carcinoma	GDSC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation altering degron motif	0.7139
p.P2134A	TCGA-CN-A640	HNSC	TCGA	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.1667
p.R2362L	TCGA-EE-A183	SKCM	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation altering degron motif	0.8428
p.G2361E	TCGA-FI-A2F4	UCEC	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation altering degron motif	0.6087
p.P1463L	TCGA-HJ-7597	STAD	TCGA	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.3056
p.P1463L	DO38195	STAD	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.3056
p.T2368N	DO225161	BRCA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation altering degron motif	0.7055
p.M2153V	DO8151	COAD	ICGC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.25
p.T1473M	DO233693	GACA	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.1944
p.R2361L	DO228900	LICA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation altering degron motif	0.8428
p.W2147L	DO228952	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation altering degron motif	0.7015
p.K2159N	DO228976	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.0833
p.V1474L	DO229027	LICA	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation rewiring degron network	0.1667
p.G2139C	DO229037	LICA	ICGC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.3056
p.D2372Y	DO229009	LICA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation substituting flanking lysine	0.3611
p.A1464S	DO50889	LICA	ICGC	AISST	DEG_SPOP_SBC_1	1464:1468	Mutation altering degron motif	0.7588
p.H2378L	DO25877	LUAD	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation blocking phosphorylation signal	0.5278
p.M2153I	DO47819	STAD	ICGC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.25
p.I2379V	DO42023	UCEC	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation blocking phosphorylation signal	0.5
p.V2152F	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2778
p.V2152F	NCI-H1299	lung	COSMIC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2778
p.E2136K	SIDM00555	Glioblastoma	GDSC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2222
p.E2136K	KS-1	central nervous system	COSMIC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2222
p.V2152G	SIDM01037	Breast Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2778
p.V2152G	JIMT-1	breast	COSMIC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2778
p.E2136G	SIDM00837	Colorectal Carcinoma	GDSC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2222
p.E2136G	SW48	large intestine	COSMIC	DSNDSSYSEPP	CBL_PTK	2140:2150	Mutation rewiring degron network	0.2222
p.R2355H	SIDM00217	Colorectal Carcinoma	GDSC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation rewiring degron network	0.1667
p.R2355H	SNU-1040	large intestine	COSMIC	GRVNLDQLE	DEG_APCC_DBOX_1	2361:2369	Mutation rewiring degron network	0.1667

Kaplan plot for ZNF462 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF462

UniProt ID: Q96JM2

Entrez ID: 58499

Protein name: Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF462 in