DegronMD

Uniprot ID: Q96JM2

Source protein: Zinc finger protein 462

Source gene: ZNF462

Class: DEG_APCC_DBOX_1

Location: 2361:2369

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.958

ASA_SCORE: 79.9778

COIL: 0.5548

CONS_SCORE: 0.6018

DSS_SCORE: 0.4851

HELIX: 0.2327

FCONS_SCORE: 1.0264

RIG_SCORE: 0.7707

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2358Q	TCGA-95-7944	LUAD	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	0.25
p.K2352N	TCGA-B5-A1MX	UCEC	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	0.1944
p.R2362L	TCGA-EE-A183	SKCM	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	0.8428
p.G2361E	TCGA-FI-A2F4	UCEC	TCGA	GRVNLDQLE	DEG_APCC_DBOX_1	0.6087
p.T2368N	DO225161	BRCA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	0.7055
p.R2361L	DO228900	LICA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	0.8428
p.D2372Y	DO229009	LICA	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	0.3611
p.H2378L	DO25877	LUAD	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	0.5278
p.I2379V	DO42023	UCEC	ICGC	GRVNLDQLE	DEG_APCC_DBOX_1	0.5
p.R2355H	SIDM00217	Colorectal Carcinoma	GDSC	GRVNLDQLE	DEG_APCC_DBOX_1	0.1667
p.R2355H	SNU-1040	large_intestine	COSMIC	GRVNLDQLE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM2	Zinc finger protein 462	DEG_APCC_DBOX_1	2361:2369	GRVNLDQLE	APC,CDC20,FZR1	0.958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons