DegronMD

Uniprot ID: Q96JM2

Source protein: Zinc finger protein 462

Source gene: ZNF462

Class: DEG_SPOP_SBC_1

Location: 1464:1468

E3 ligase: SPOP

DEGRON score: 0.9393

ASA_SCORE: 84.76

COIL: 0.9352

CONS_SCORE: 0.606

DSS_SCORE: 0.2864

HELIX: 0.0314

FCONS_SCORE: 0.9977

RIG_SCORE: 0.6768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1471K	TCGA-55-6979	LUAD	TCGA	AISST	DEG_SPOP_SBC_1	0.25
p.Q1471K	DO24110	LUAD	ICGC	AISST	DEG_SPOP_SBC_1	0.25
p.A1464T	TCGA-B7-A5TI	STAD	TCGA	AISST	DEG_SPOP_SBC_1	0.7139
p.A1464T	DO222328	STAD	ICGC	AISST	DEG_SPOP_SBC_1	0.7139
p.A1464T	SIDM02059	Colorectal Carcinoma	GDSC	AISST	DEG_SPOP_SBC_1	0.7139
p.P1463L	TCGA-HJ-7597	STAD	TCGA	AISST	DEG_SPOP_SBC_1	0.3056
p.P1463L	DO38195	STAD	ICGC	AISST	DEG_SPOP_SBC_1	0.3056
p.T1473M	DO233693	GACA	ICGC	AISST	DEG_SPOP_SBC_1	0.1944
p.V1474L	DO229027	LICA	ICGC	AISST	DEG_SPOP_SBC_1	0.1667
p.A1464S	DO50889	LICA	ICGC	AISST	DEG_SPOP_SBC_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons