DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SPOP_SBC_1

Location: 124:128

E3 ligase: SPOP

DEGRON score: 0.9744

ASA_SCORE: 76.2

COIL: 0.9074

CONS_SCORE: 0.3632

DSS_SCORE: 0.4275

HELIX: 0.061

FCONS_SCORE: 0.9432

RIG_SCORE: 0.7235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G134D	TCGA-A5-A0G2	UCEC	TCGA	AISST	DEG_SPOP_SBC_1	0.1667
p.G134D	DO41235	UCEC	ICGC	AISST	DEG_SPOP_SBC_1	0.1667
p.P137S	TCGA-A6-3807	COAD	TCGA	AISST	DEG_SPOP_SBC_1	0.0833
p.P137S	DO9034	COAD	ICGC	AISST	DEG_SPOP_SBC_1	0.0833
p.T128I	TCGA-D1-A103	UCEC	TCGA	AISST	DEG_SPOP_SBC_1	0.7078
p.T128I	DO42312	UCEC	ICGC	AISST	DEG_SPOP_SBC_1	0.7078
p.P137L	TCGA-EE-A2MR	SKCM	TCGA	AISST	DEG_SPOP_SBC_1	0.0833
p.P137L	DO37819	SKCM	ICGC	AISST	DEG_SPOP_SBC_1	0.0833
p.A124D	DO228971	LICA	ICGC	AISST	DEG_SPOP_SBC_1	0.7793
p.N120Y	ACH-000831	Endometrial/Uterine Cancer	CCLE	AISST	DEG_SPOP_SBC_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons