DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DSNGYTNLP
Uniprot ID:
Q8N4C8
Source protein:
Misshapen-like kinase 1
Source gene:
MINK1
Class:
CBL_PTK
Location:
902:910
E3 ligase:
CBL
DEGRON score:
0.9736
ASA_SCORE:
73.6
COIL:
0.8401
CONS_SCORE:
0.2822
DSS_SCORE:
0.6806
HELIX:
0.0739
FCONS_SCORE:
0.8998
RIG_SCORE:
0.6567
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S919Y
KCL-22
haematopoietic_and_lymphoid_tissue
COSMIC
DSNGYTNLP
CBL_PTK
0.0833
p.S910Y
KCL-22
haematopoietic_and_lymphoid_tissue
COSMIC
DSNGYTNLP
CBL_PTK
0.712
Drug responses associated with MINK1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSNGYTNLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N4C8
Misshapen-like kinase 1
CBL_PTK
902:910
DSNGYTNLP
CBL
0.9736
More...
