DegronMD - Q8N4C8(MINK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R890H	TCGA-19-1787	GBM	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.R890H	TCGA-CA-6717	COAD	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.R890H	TCGA-KU-A66S	HNSC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.R890H	DO8264	COAD	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.R890H	DO13522	GBM	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.R890H	DO44456	HNSC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.7133
p.S651N	TCGA-AJ-A3OL	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.2778
p.S651N	DO43001	UCEC	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.2778
p.V888I	TCGA-CV-A45W	HNSC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.5965
p.V888I	DO52060	HNSC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.5965
p.R890C	TCGA-D1-A16F	UCEC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.719
p.R890C	DO222817	BTCA	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.719
p.R890C	DO42408	UCEC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.719
p.P666S	TCGA-DF-A2KU	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.1944
p.P666S	DO223286	UCEC	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.1944
p.P879S	TCGA-GN-A26C	SKCM	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation rewiring degron network	0.0833
p.P879S	DO37782	SKCM	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation rewiring degron network	0.0833
p.P660S	TCGA-VS-A8EC	CESC	TCGA	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.6752
p.P660S	DO51618	CESC	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.6752
p.R659H	DO229016	COCA	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00370	T-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00251	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00299	Other Sarcomas	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00498	Colorectal Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM01146	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00289	B-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM01033	Bladder Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM01471	Chronic Myelogenous Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.R659H	SIDM00164	Biliary Tract Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7133
p.P654H	DO234219	ESAD	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7694
p.G647A	DO228330	LICA	ICGC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.1667
p.H900R	DO227648	PACA	ICGC	RNLLHAD	LIG_APCC_ABBAyCdc20_2	896:902	Mutation altering degron motif	0.8244
p.T885I	DO229253	THCA	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation rewiring degron network	0.25
p.E893V	SIDM00789	Colorectal Carcinoma	GDSC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.6582
p.E893V	ACH-000997	Colon/Colorectal Cancer	CCLE	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.6582
p.E893V	ACH-001061	Colon/Colorectal Cancer	CCLE	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.6582
p.E893V	HCT-15	large intestine	COSMIC	VQRTPEEE	DEG_SCF_FBW7_2	888:895	Mutation altering degron motif	0.6582
p.P654S	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.6752
p.P654S	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.6752
p.P654S	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.6752
p.P654L	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7582
p.P654L	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7582
p.P654L	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation altering degron motif	0.7582
p.S651G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.2778
p.S919Y	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSNGYTNLP	CBL_PTK	902:910	Mutation rewiring degron network	0.0833
p.S910Y	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSNGYTNLP	CBL_PTK	902:910	Mutation altering degron motif	0.712
p.T652A	SW756	cervix	COSMIC	NPPAWVRPD	DEG_SIAH_1	653:661	Mutation rewiring degron network	0.3056

Kaplan plot for MINK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MINK1

UniProt ID: Q8N4C8

Entrez ID: 50488

Protein name: Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MINK1 in