DegronMD

Uniprot ID: Q8N4C8

Source protein: Misshapen-like kinase 1

Source gene: MINK1

Class: DEG_SCF_FBW7_2

Location: 888:895

E3 ligase: FBXW7

DEGRON score: 0.5335

ASA_SCORE: 91.0125

COIL: 0.5824

CONS_SCORE: 0.2788

DSS_SCORE: 0.6461

HELIX: 0.1255

FCONS_SCORE: 0.9888

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R890H	TCGA-19-1787	GBM	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.R890H	TCGA-CA-6717	COAD	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.R890H	TCGA-KU-A66S	HNSC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.R890H	DO8264	COAD	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.R890H	DO13522	GBM	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.R890H	DO44456	HNSC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.7133
p.V888I	TCGA-CV-A45W	HNSC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.5965
p.V888I	DO52060	HNSC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.5965
p.R890C	TCGA-D1-A16F	UCEC	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.719
p.R890C	DO222817	BTCA	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.719
p.R890C	DO42408	UCEC	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.719
p.P879S	TCGA-GN-A26C	SKCM	TCGA	VQRTPEEE	DEG_SCF_FBW7_2	0.0833
p.P879S	DO37782	SKCM	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.0833
p.T885I	DO229253	THCA	ICGC	VQRTPEEE	DEG_SCF_FBW7_2	0.25
p.E893V	SIDM00789	Colorectal Carcinoma	GDSC	VQRTPEEE	DEG_SCF_FBW7_2	0.6582
p.E893V	ACH-000997	Colon/Colorectal Cancer	CCLE	VQRTPEEE	DEG_SCF_FBW7_2	0.6582
p.E893V	ACH-001061	Colon/Colorectal Cancer	CCLE	VQRTPEEE	DEG_SCF_FBW7_2	0.6582
p.E893V	HCT-15	large_intestine	COSMIC	VQRTPEEE	DEG_SCF_FBW7_2	0.6582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4C8	Misshapen-like kinase 1	DEG_SCF_FBW7_2	888:895	VQRTPEEE	FBXW7	0.5335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons