DegronMD

Uniprot ID: Q8N4C8

Source protein: Misshapen-like kinase 1

Source gene: MINK1

Class: DEG_SIAH_1

Location: 653:661

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9517

ASA_SCORE: 98.3

COIL: 0.9414

CONS_SCORE: 0.2436

DSS_SCORE: 0.7668

HELIX: 0.0259

FCONS_SCORE: 0.9603

RIG_SCORE: 0.6124

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S651N	TCGA-AJ-A3OL	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.2778
p.S651N	DO43001	UCEC	ICGC	NPPAWVRPD	DEG_SIAH_1	0.2778
p.P666S	TCGA-DF-A2KU	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.1944
p.P666S	DO223286	UCEC	ICGC	NPPAWVRPD	DEG_SIAH_1	0.1944
p.P660S	TCGA-VS-A8EC	CESC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P660S	DO51618	CESC	ICGC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.R659H	DO229016	COCA	ICGC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00370	T-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00251	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00299	Other Sarcomas	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00498	Colorectal Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01146	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00289	B-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01033	Bladder Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01471	Chronic Myelogenous Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00164	Biliary Tract Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.P654H	DO234219	ESAD	ICGC	NPPAWVRPD	DEG_SIAH_1	0.7694
p.G647A	DO228330	LICA	ICGC	NPPAWVRPD	DEG_SIAH_1	0.1667
p.P654S	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654S	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654S	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654L	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7582
p.P654L	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	0.7582
p.P654L	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.7582
p.S651G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.2778
p.T652A	SW756	cervix	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NPPAWVRPD

Degron related mutations and impact score

Drug responses associated with MINK1 mutations

All proteins holding degron of NPPAWVRPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4C8	Misshapen-like kinase 1	DEG_SIAH_1	653:661	NPPAWVRPD	SIAH1,SIAH2,SIAH3	0.9517	More...