DegronMD

Uniprot ID: Q8N4C8

Source protein: Misshapen-like kinase 1

Source gene: MINK1

Class: DEG_SIAH_1

Location: 653:661

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9517

ASA_SCORE: 98.3

COIL: 0.9414

CONS_SCORE: 0.2436

DSS_SCORE: 0.7668

HELIX: 0.0259

FCONS_SCORE: 0.9603

RIG_SCORE: 0.6124

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P654H	DO234219	ESAD	ICGC	NPPAWVRPD	DEG_SIAH_1	0.7694
p.P654L	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7582
p.P654L	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	0.7582
p.P654L	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.7582
p.R659H	DO229016	COCA	ICGC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00370	T-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00251	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00299	Other Sarcomas	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00498	Colorectal Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01146	Gastric Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00289	B-Lymphoblastic Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01033	Bladder Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM01471	Chronic Myelogenous Leukemia	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.R659H	SIDM00164	Biliary Tract Carcinoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.7133
p.P660S	TCGA-VS-A8EC	CESC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P660S	DO51618	CESC	ICGC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654S	SIDM00007	Other Solid Cancers	GDSC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654S	ACH-001550	Skin Cancer	CCLE	NPPAWVRPD	DEG_SIAH_1	0.6752
p.P654S	MCC13	skin	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.6752
p.T652A	SW756	cervix	COSMIC	NPPAWVRPD	DEG_SIAH_1	0.3056
p.S651N	TCGA-AJ-A3OL	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.2778
p.S651N	DO43001	UCEC	ICGC	NPPAWVRPD	DEG_SIAH_1	0.2778
p.S651G	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	NPPAWVRPD	DEG_SIAH_1	0.2778
p.P666S	TCGA-DF-A2KU	UCEC	TCGA	NPPAWVRPD	DEG_SIAH_1	0.1944

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Drug responses associated with MINK1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of NPPAWVRPD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4C8	Misshapen-like kinase 1	DEG_SIAH_1	653:661	NPPAWVRPD	SIAH1,SIAH2,SIAH3	0.9517	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NPPAWVRPD

Degron related mutations and impact score

Drug responses associated with MINK1 mutations

All proteins holding degron of NPPAWVRPD