DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_COP1_1

Location: 1741:1751

E3 ligase: COP1

DEGRON score: 0.9668

ASA_SCORE: 98.7909

COIL: 0.921

CONS_SCORE: 0.3563

DSS_SCORE: 0.3961

HELIX: 0.0652

FCONS_SCORE: 0.8425

RIG_SCORE: 0.6828

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1751G	TCGA-20-0991	OV	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.754
p.A1751G	DO31949	OV	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.754
p.D1738H	TCGA-4Z-AA87	BLCA	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.25
p.D1738H	DO218990	BLCA	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.25
p.S1757F	TCGA-A5-A0G2	UCEC	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.1667
p.S1757F	TCGA-F7-A61S	HNSC	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.1667
p.S1757F	DO44427	HNSC	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.1667
p.S1757F	DO41235	UCEC	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.1667
p.A1733V	TCGA-B5-A3FC	UCEC	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.1111
p.A1733V	DO41871	UCEC	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.1111
p.A1733V	SIDM00238	Ovarian Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	0.1111
p.P1752S	TCGA-D9-A4Z6	SKCM	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.3056
p.P1752S	DO47485	SKCM	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.3056
p.A1733T	TCGA-JW-AAVH	CESC	TCGA	DSQHSTPVPTA	DEG_COP1_1	0.1111
p.A1733T	DO51605	CESC	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.1111
p.P1749H	DO229028	LICA	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.7694
p.D1731E	DO229006	LICA	ICGC	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731V	SIDM00683	Prostate Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731V	ACH-000977	lymph_node	CCLE	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731V	LNCaP-Clone-FGC	prostate	COSMIC	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731G	SIDM00860	Head and Neck Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731G	ACH-000846	Head and Neck Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1731G	FADU	upper_aerodigestive_tract	COSMIC	DSQHSTPVPTA	DEG_COP1_1	0.0556
p.D1738G	SIDM00713	Mesothelioma	GDSC	DSQHSTPVPTA	DEG_COP1_1	0.25
p.D1738G	ACH-000153	Lung Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	0.25
p.D1738G	NCI-H2052	pleura	COSMIC	DSQHSTPVPTA	DEG_COP1_1	0.25
p.H1744Y	SIDM00783	Colorectal Carcinoma	GDSC	DSQHSTPVPTA	DEG_COP1_1	0.6118
p.H1744Y	ACH-000971	Colon/Colorectal Cancer	CCLE	DSQHSTPVPTA	DEG_COP1_1	0.6118
p.H1744Y	HCT-116	large_intestine	COSMIC	DSQHSTPVPTA	DEG_COP1_1	0.6118

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSQHSTPVPTA

Degron related mutations and impact score

Drug responses associated with ANKRD11 mutations

All proteins holding degron of DSQHSTPVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_COP1_1	1741:1751	DSQHSTPVPTA	COP1	0.9668	More...